[50] Formation of bimolecular membranes from lipid monolayers
Methods in enzymology on CD-ROM/Methods in enzymologyPublished 1 January 1974
M Montal
Citations130
SJR quartileQ4
SJR score0.13
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Abstract
The use of lipid bilayer as a relevant model of biological membranes has provided important information about the structure and function of cell membranes. Particularly impressive has been the advance in the theoretical and experimental evaluation of the carrier and channel mechanisms of ion transport across membranes and that of electrical excitability. This progress has been achieved by the success in introducing small peptides and membrane active antibiotics into planar bilayer containing hydrocarbon solvents. In contrast, attempts to introduce large and defined membrane proteins in a functionally active state have met with considerable difficulties. The failures may be attributed to the presence of hydrocarbons or to the inability of the proteins to interact adequately with a preformed bilayer.
Keywords
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