Polycomb group protein-mediated repression of transcription
Trends in Biochemical SciencesPublished 25 March 2010
Lluís Morey, Kristian Helin
Citations376
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms and form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development.
Abstract
The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2.
Keywords
Biochemistry, Genetics and Molecular Biology
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Biochemical JournalPolycomb protein Cbx4 promotes SUMO modification of <i>de novo</i> DNA methyltransferase Dnmt3a
99 Citations2007Bing Li, Jing Zhou +6 more
The results suggest that Cbx4 functions as a SUMO E3 ligase for Dnmt3a and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification.
Journal of Biological ChemistryStructural Organization of a Sex-comb-on-midleg/Polyhomeotic Copolymer
88 Citations2005Chongwoo A. Kim, M.R. Sawaya +3 more
The copolymer model suggests that polymeric Scm complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression.
BiochemistryHuman Cystathionine β-Synthase Is a Target for Sumoylation
74 Citations2006Ömer Kabil, You Zhou +1 more
The discovery that CBS is a target of sumoylation adds another layer to the complex regulation of this enzyme and reveals a previously unknown residence for this protein, i.e., in the nucleus.
EpigeneticsThe ZNF217 oncogene is a candidate organizer of repressive histone modifiers
71 Citations2009Michaela S. Banck, SiDe Li +4 more
It is suggested that ZNF217 assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression.
PLoS ONEThe Polycomb Repressive Complex 2 Is a Potential Target of SUMO Modifications
64 Citations2008Eva M. Riising, Roberto Boggio +3 more
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