Characteristic purpura of the ears, vasculitis, and neutropenia–a potential public health epidemic associated with levamisole-adulterated cocaine

It appears the use of cocaine is associated with the peculiar clinical findings of ear purpura, retiform purPura of the trunk, and neutropenia, and this case series may represent the tip of the iceberg as a looming public health problem caused by levamisole.

Abstract

It appears the use of cocaine is associated with the peculiar clinical findings of ear purpura, retiform purpura of the trunk, and neutropenia. We believe this case series may represent the tip of the iceberg as a looming public health problem caused by levamisole. Although the direct causal relationship may be difficult to establish, the astute dermatologist or primary care physician should be able to recognize the characteristic skin lesions and should be wary of the potential development of agranulocytosis.