THE INHIBITORY ACTION OF NALORPHINE ON THE ENZYMATIC N-DEMETHYLATION OF NARCOTIC DRUGS
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TL;DR
Nalorphine and its analogues inhibit the N-demethylation of morphine and other narcotic drugs in rat-liver microsomal preparations by enzymes in the rat liver microsomes and soluble supernatant fraction, which require triphosphopyridine nucleotide.
Abstract
Nalorphine and its analogues inhibit the N-demethylation of morphine and other narcotic drugs in rat-liver microsomal preparations. N-substituted normorphine derivatives with a 3-carbon chain linked to the nitrogen atom are the most potent inhibitors. Nalorphine is dealkylated to normorphine by enzymes in the rat liver microsomes and soluble supernatant fraction, which require triphosphopyridine nucleotide.