Therapy of fungal infections.
PubMedPublished 1 November 1982Open access
Drutz Dj
Citations3
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TL;DR
For all its many problems, amphotericin B cannot be faulted on the basis of easy acquisition of drug resistance, and remains quite rare, although there are case reports of its occurrence under conditions of immunosuppression.
Keywords
Medicine
DrugsEconazole
298 Citations1978R.C. Heel, Rex N. Brogden +2 more
The cure rate was only slightly lower in patients with severe mycoses of many years’ duration than in those whose infections were of more recent onset, and the exact mechanism of econazole’s antimicrobial activity has not been conclusively determined.
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A decade of experience has shown amphotericin B to be the most useful broad-spectrum antifungal antibiotic, yet many practical questions concerning its use have remained unanswered, including the relative efficacy of intravenous infusion every day (QD) versus every other day ( QOD).
Experimental Biology and MedicineSynergistic Action of Amphotericin B and 5-Fluorocytosine Against Yeast-Like Organisms
229 Citations1971Gerald Medoff, Monago-Ighorodje C. Comfort +1 more
The efficacy of amphotericin B and 5-fluorocytosine used in combination against several different isolates of Cryptococcus neoformans,Candida albicans, Candida tropicalis, and Saccharomyces cerevisiae has been investigated in vitro.
Clinical Infectious DiseasesMechanism of Action of Antifungal Drugs, with Special Reference to the Imidazole Derivatives
220 Citations1980Μ. Borgers
The imidazole derivatives inhibit the transformation of blastospores of Candida albicans into the invasive mycelial form and probably facilitates the task of host defense cells and may be the principal factor leading to clearance of infection.
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140 Citations1980ESKlLD A. PETERSEN, DAVID W. ALLING +1 more
Oral ketoconazole is an effective treatment for chronic mucocutaneous candidiasis and Hepatitis developed in one patient after 6 months of treatment but proved to be mild and reversible.
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134 Citations1974K.H. Sreedhara Swamy, M Sirsi +1 more
It is shown that the antifungal drug alters the cellular permeability, and thus the exogenous respiration becomes sensitive to the drug.
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An atypical variant of Candida tropicalis was recovered from multiple specimens from a patient who had been a recipient of a bone marrow transplant and showed atypicals morphology on corn meal agar distinguishable from typical isolates of C. tropicalis.
CRC Critical Reviews in BiochemistrySpeculations on the Evolution of Sterol Structure and Functio
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The finding that cholesterylmethyl ether satisfies the sterol requirement of certain microbial systems is at variance with current views on the role played by the sterols hydroxyl group in membrane organization and function.
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84 Citations1976Ward E. Bullock, Robert Luke +2 more
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71 Citations1971Thomas H. Gouge, Vincent T. Andriole
Observations suggest that amphotericin nephrotoxicity is produced, at least in part, by a tubular defect in acid excretion and that alkali therapy may possibly prevent the progressive renal damage often associated with this drug.
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70 Citations1972M. A. Burgess, Gerald P. Bodey
In six patients taking 1.5 g of clotrimazole every 6 hr, there was a progressive decline in the serum concentrations after administration of a dose on days 1, 4, and 8, and nine other patients begun on a similar schedule manifested gastrointestinal symptoms attributed to the clotrimzole and were unable to complete the study.
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It is suggested that ketoconazole may be effective for treatment of this disease and indicate that trials comparing the efficacy of ketconazole with that of amphotericin B are warranted.
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66 Citations1980John R. Graybill, DAVID J. DRUTZ
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65 Citations1980Victor Fainstein, Gerald P. Bodey
Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions, and all the episodes occurred after the first dose was administered.
The American Journal of the Medical SciencesDevelopment of amphotericin B-resistant Candida tropicalis in a patient with defective leukocyte function
58 Citations1978David J. Drutz, Robert I. Lehrer
In patients with defective antimicrobial defenses, amphotericin B-resistant fungi may survive, produce progressive infection, and require alternative chemotherapy for eradication.
Journal of Antimicrobial ChemotherapyDistribution of doubly radiolabelled amphotericin B methyl ester and amphotericin B in the non-human primate, <i>Macaca mulatta</i>
48 Citations1980Ruth M. Lawrence, Paul D. Hoeprich +4 more
Antimicrobial Agents and ChemotherapyEffect of Fatty Acyl Group and Sterol Composition on Sensitivity of Lecithin Liposomes to Imidazole Antimycotics
46 Citations1979Hideyo Yamaguchi, Kazuo Iwata
Negatively charged liposomes were more sensitive to the three imidazole drugs than positively charged Liposome models, primarily dependent upon the lecithin fatty acyl group composition.
Antimicrobial Agents and ChemotherapyComparative Toxicological Studies of Amphotericin B Methyl Ester and Amphotericin B in Mice, Rats, and Dogs
43 Citations1976G. R. Keim, Peter L. Sibley +5 more
It is concluded that amphotericin B methyl ester has the potential for an improved therapeutic ratio in the treatment of systemic mycoses.
Antimicrobial Agents and ChemotherapyComparative Chemotherapeutic Activity of Amphotericin B and Amphotericin B Methyl Ester
29 Citations1975D P Bonner, Ram P. Tewari +3 more
AME, like amphotericin B, was effective against each of the experimental infections, but the efficacy was lower than the parent compound.
Antimicrobial Agents and ChemotherapyComparative Pharmacology of Amphotericin B and Amphotericin B Methyl Ester in the Non-Human Primate, <i>Macaca mulatta</i>
28 Citations1977F. A. Jagdis, Paul D. Hoeprich +2 more
AME was less toxic and achieved a greater urinary outfall than AMB, and the antifungal activity of AME is comparable to that of AMB by testing in vitro, further study is warranted.
American Journal of Tropical Medicine and HygieneParacoccidioidomycosis (South American Blastomycosis): Treatment with Miconazole
27 Citations1978David A. Stevens, Angela Restrepo-M. +4 more
PubMedThe effects of amphotericin B therapy on the intrarenal vasculature and renal tubules in man. A study of biopsies by light, electron and immunofluorescence microscopy.
25 Citations1978Bhathena Db, Bullock We +2 more
Renal morphology was studied by light and electron microscopy in 10 patients after 25 mg/kg body weight of amphotericin B as part of a controlled study designed to evaluate the possible protective effects of mannitol against the nephrotoxicity of amph esotericin B.
Antimicrobial Agents and ChemotherapyInhibition of Potentially Pathogenic Yeastlike Fungi by Clotrimazole in Combination with 5-Fluorocytosine or Amphotericin B
25 Citations1976William H. Beggs, George A. Sarosi +1 more
It would appear that weak inhibitory concentrations of CTM can act together with 5-FC or AMB to produce antifungal effects greater than that obtained with either of the latter two drugs alone.
The Journal of Infectious DiseasesAmphotericin B and Amphotericin B Methyl Ester Ascorbate. I. Chemotherapeutic Activity against Candida albicans, Cryptococcus neoformans, and Blastomyces dermatitidis in Mice
20 Citations1976H. H. Gadebusch, F. E. Pansy +2 more
It is shown that AME, as the ascorbate salt, is substantially less efficacious than amphotericin B (in colloidal dispersion with sodium deoxycholate) for treatment of the fungal infections and that amphoteric in B had a higher therapeutic ratio for all infections studied than did AME.
PubMedTreatment of coccidioidomycosis with miconazole.
10 Citations1980Paul D. Hoeprich, Ruth M. Lawrence +1 more