Polymyxin B octapeptide and polymyxin B heptapeptide are potent outer membrane permeability-increasing agents.
The Journal of AntibioticsPublished 1 January 1992Open access
Yukio Kimura, Hisami Matsunaga, Martti Vaara
Citations55
SJR quartileQ3
SJR score0.48
SNIP0.83
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TL;DR
PBOP was as effective as polymyxin B nonapeptide (PMBN), the known very potent permeabilizer, and only a slightly higher concentration of PBHP was required for a similar sensitizing effect.
Abstract
Polymyxin B octapeptide (PBOP) and polymyxin B heptapeptide (PBHP) were found to be effective permeabilizers of the outer membrane of Escherichia coli and Salmonella typhimurium. PBOP was as effective as polymyxin B nonapeptide (PMBN), the known very potent permeabilizer. As low a PBOP concentration as 1 microgram/ml sensitized E. coli to rifampicin by a factor of 100. Three micrograms of PBOP per ml was sufficient to sensitize this target to all the other tested hydrophobic antibiotics (erythromycin, fusidic acid, clindamycin, and novobiocin) by a factor of 30. Only a slightly higher (3-fold) concentration of PBHP was required for a similar sensitizing effect.
Keywords
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