A Simple Stereocontrolled Synthesis of Salinosporamide A
Journal of the American Chemical SocietyPublished 22 April 2004
Leleti Rajender Reddy, P. Saravanan, E. J. Corey
Citations245
SJR quartileQ1
SJR score5.55
SNIP2.61
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Abstract
A simple and effective stereocontrolled synthesis of salinosporamide A has been developed. This process, the first synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. Salinosporamide A was of special interest as a synthetic target because of its potent in vitro cytotoxic activity against many tumor cell lines (IC(50) values of 10 nM or less).
Keywords
ChemistryMedicineBiochemistry, Genetics and Molecular Biology
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