Olfactory deprivation enhances normal spine loss in the olfactory bulb of developing ferrets
Neuroscience LettersPublished 1 December 1985
Raimund Apfelbach, E Weiler
Citations26
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
In ferrets, exposed continuously to saturated levels of geraniol odor in the cage environment, the normal decline in spine number is significantly enhanced and the significance of these events to olfactory imprinting and plasticity in the developing brain is discussed.
Abstract
Ferrets show a sensitive phase in their postnatal development during which they can become imprinted to food odors. At the same time the number of granule cell spines in the olfactory bulb reaches a maximum, declining significantly thereafter. In ferrets, exposed continuously to saturated levels of geraniol odor in the cage environment, the normal decline in spine number (occurring between day 60 and 90) is significantly enhanced. No such effects were observed during earlier ontogenetic phases. This late postnatal phase is further associated with a marked and significant decrease in total brain weight. The significance of these events to olfactory imprinting and plasticity in the developing brain is discussed.
Keywords
PsychologyMedicineBiochemistry, Genetics and Molecular Biology
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