The feasibility of online genetic testing for lung cancer susceptibility: uptake of a web-based protocol and decision outcomes
Genetics in MedicinePublished 1 February 2008Open access
Suzanne C. O’Neill, Della Brown White, Saskia C. Sanderson, Isaac M. Lipkus, Gerold Bepler, Lori A. Bastian
Citations33
SJR quartileQ1
SJR score2.68
SNIP2.38
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TL;DR
Internet-delivered decision support was as likely as other modalities to yield informed decisions to yieldinformed decisions and some subgroups may need additional support to improve their decision outcomes.
Abstract
Interest in a web-based protocol for genetic susceptibility testing was high. Internet-delivered decision support was as likely as other modalities to yield informed decisions. Some subgroups may need additional support to improve their decision outcomes.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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10,770 Citations1991Todd F. Heatherton, Lynn T. Kozlowski +2 more
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Advances in experimental social psychologyThe Elaboration Likelihood Model of Persuasion
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This chapter discusses a wide variety of variables that proved instrumental in affecting the elaboration likelihood, and thus the route to persuasion, and outlines the two basic routes to persuasion.
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The meta-analysis suggests that strong fear appeals produce high levels of perceived severity and susceptibility, and are more persuasive than low or weak fear appeals, and the results indicate that fear appeals motivate adaptive danger control actions such as message acceptance and maladaptive fear control actionssuch as defensive avoidance or reactance.
Psychological BulletinThe theory of decision making.
2,671 Citations1954Ward Edwards
This literature review of decision making (how people make choices among desirable alternatives), culled from the disciplines of psychology, economics, and mathematics, covers the theory of riskless choices, the application of the theory to welfare economics,The theory of risky choices, transitivity of choices, and the theories of games and statistical decision functions.
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Research in TMs could be improved by giving greater attention to assessment of conceptually grounded cognitive and emotional variables, appropriately timed assessment and intervention, and inclusion of appropriate target and comparison samples.
Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjectsThe Isoenzymes of Glutathione Transferase
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PubMedAttitudes toward colon cancer gene testing: factors predicting test uptake.
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PubMedGlutathione S-transferase M1 status and lung cancer risk: a meta-analysis.
142 Citations1999Richard S. Houlston
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American Journal of Medical GeneticsSelf‐selection in predictive testing for Huntington's disease
132 Citations1994Ann‐Marie Codori, Rebecca Hanson +1 more
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