Vasopressin analogues with selective pressor activity
Cellular and Molecular Life SciencesPublished 1 January 1964
B. Berde, R. A. Boissonnas, R Huguenin, E. Stürmer
Citations56
SJR quartileQ1
SJR score2.30
SNIP1.48
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TL;DR
Die Synthese und die pharmakologischen Haupteigenschaften von Orn8-Vasopressin, Phe2-Orn8-vasoppressin, Orn 8-Oxytocin werden beschrieben und die pressorische Aktivität dieser Peptide zeigt eine in der Reihenfolge zunehmende Selektivitayt.
Abstract
Die Synthese und die pharmakologischen Haupteigenschaften von Orn8-Vasopressin, Phe2-Orn8-Vasopressin, Orn8-Oxytocin und Phe2-Orn8-Oxytocin werden beschrieben. Die pressorische Aktivität dieser Peptide zeigt eine in der Reihenfolge zunehmende Selektivität.
Keywords
PsychologyChemistry
British Journal of Pharmacology and ChemotherapyA MODIFICATION OF THE METHOD OF DALE AND LAIDLAW FOR STANDARDIZATION OF POSTERIOR PITUITARY EXTRACT
242 Citations1948Pamela Holton
The activity of a posterior pituitary extract is still generally determined by the method intro-duced by Dale and Laidlaw (1912), which used the uterus of a virgin guinea-pig to set limits to the potency of the test solution in terms of the standard solution by the usual ABBA grouping of doses.
Helvetica Chimica ActaUne nouvelle synthèse de l'oxytocine
205 Citations1955R. A. Boissonnas, St. Guttmann +4 more
A new synthesis of oxytocin is described, where the CBO group is removed by HBr in acetic acid and the hexapeptide is condensed with N-CBO-S-benzyl-L-cysteinyl- L-tyrosyl- l-isoleucyl-azide to give the nonapeptides.
EndocrinologyDIFFERENCES IN THE ANTIDIURETIC RESPONSES OF RATS TO THE INTRAVENOUS ADMINISTRATIONOF LYSINE AND ARGININE VASOPRESSINS<sup>1</sup>
119 Citations1958Wilbur H. Sawyer
When injected intravenously into rats anesthetized by ethanol, lysine vaso-pressin causes an antidiuresis that is as intense as that caused by arginine vasa pressin but its duration is, however, less.
Cellular and Molecular Life SciencesRelationships between the chemical structures and the biological properties of the posterior pituitary hormones and their synthetic analogues
119 Citations1961R. A. Boissonnas, St. Guttmann +2 more
Cette confrontation montre qu'il est possible of découvrir quelques relations limitées entre la spécificité biologique de ces corps et certaines particularités de leur structure.
Experimental Biology and MedicineA Method for Demonstrating an Antidiuretic Action of Minute Amounts of Pitressin: Statistical Analysis of Results.
112 Citations1942William A. Jeffers, M. M. Livezey +1 more
As an assay technic, using the same number of injections, this test is at least as reliable as the multiple rat test of Burn, 1 and as other tests available for antidiuretic substances.
PubMedThird international standard for posterior pituitary; re-named third international standard for oxytocic, vasopressor and antidiuretic substances in 1956.
52 Citations1958D. R. Bangham, Marjorie V. Mussett
The potency of the Third Standard (re-named International Standard for Oxytocic, Vasopressor and Antidiuretic Substances in 1956, in view of the recent synthesis of oxytocin and vasopressin) should be expressed as 2.0 International Units per milligram.
Helvetica Chimica ActaSynthèses de la Phé<sup>2</sup>‐arginine‐vasopressine et de la Phé<sup>2</sup>‐arginine‐vasotocine et nouvelles synthèses de l'argininevasopressine et de l'arginine‐vasotocine
49 Citations1962R Huguenin, R. A. Boissonnas
Absence of the phenolic hydroxyl group decreases the main biological activities, but in a lower extent than in the corresponding families of oxytocin and lysine-vasopressin.
Archives of Biochemistry and BiophysicsThe synthesis of the histidine analog of the vasopressins
34 Citations1958Panayotis G. Katsoyannis, Vincent du Vigneaud
It would appear that the relative basicity of the amino acid residue in the penultimate position in the side chain of the posterior pituitary hormones has a considerable influence on the degree of pressor activity of these compounds.
Helvetica Chimica ActaSynthèse de l'Orn<sup>8</sup>‐vasopressine et de l'Orn<sup>8</sup>‐oxytocine
29 Citations1963R Huguenin, R. A. Boissonnas
Orn8-vasopressin and Orn8-oxytocin have been synthesized and their biological activities compared with those of arginine-vas Opressin, and the replacement of theArginine or lysine residues by an ornithin residue to not considerably affect the oxytocic and pressorie activities.
EndocrinologyAntidiuretic Responses to Neurohypophysial Hormones and Some of Their Synthetic Analogues in Dogs and Rats
27 Citations1962Wilbur H. Sawyer, Wood Yee Chan +1 more
The known neurohypophysial hormones and several synthetic analogues containing substituted amino acids in the side chain were injected intravenously into hydra ted dogs and rats to determine the relative antidiuretic activities of the peptides in dogs and Rats.
Helvetica Chimica ActaSynthèse de la Dé‐Pro<sup>7</sup>‐oxytocine, de la Dé‐Leu<sup>8</sup>‐oxytocine et de la Dé‐Gly<sup>9</sup>‐oxytocine
25 Citations1962P Jaquenoud, R. A. Boissonnas
Three new analogues of Oxytocin in which one of the amino-acids of the peptidic side-chain has been omitted have been synthesized according to the scheme (3+5).