Synaptic frequency response: the influence of sinusoidal changes in stimulation frequency on the amplitude of the end‐plate potential
The Journal of PhysiologyPublished 1 January 1973Open access
E. M. Landau, Y. Lass
Citations4
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TL;DR
The synaptic response to frequency modulated trains of stimuli was investigated at the neuromuscular junction of the frog and the frequency of stimulation usually varied sinusoidally about a carrier frequency of ca.
Abstract
1. The synaptic response to frequency modulated trains of stimuli was investigated at the neuromuscular junction of the frog. The frequency of stimulation was usually varied sinusoidally about a carrier frequency of ca. 25 impulses per sec (Hz).2. The post-synaptic response to sinusoidally modulated trains of nerve stimuli was found to grow almost linearly when the variations in input frequency were increased up to 60% of the carrier frequency.3. The synaptic frequency response (gain and phase) was reminiscent of that of a low-pass filter, best transmitting slow variations in input frequency.4. The synaptic filter characteristics could not be explained by the post-synaptic cable properties, but were attributed to presynaptic facilitation processes.
Keywords
Neuroscience
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