Asthma
New England Journal of MedicinePublished 31 December 1992
E.R. McFadden, Ileen Gilbert
Citations225
SJR quartileQ1
SJR score19.08
SNIP13.47
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Abstract
There is an active inflammatory process in the airways of patients with asthma, even when the patients are asymptomatic. Some of the types of cells involved in this process possess the necessary biologic activities to produce many of the pathophysiologic features of asthma, but the underlying mechanisms have not yet been elucidated. Reducing the severity of the inflammatory process appears to be a reasonable goal of therapy, with potential long-range implications for the morbidity of asthma. Whether this theoretical benefit will be realized awaits further observation.
Keywords
MedicineHealth Professions
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878 Citations1990May Azzawi, Brian Bradley +8 more
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670 Citations1990Charlotte E. P. Brewster, Peter Howarth +4 more
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American Review of Respiratory DiseaseEffect of an Inhaled Corticosteroid on Airway Inflammation and Symptoms in Asthma
645 Citations1992Ratko Djukanović, John Wilson +6 more
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620 Citations1982André Cartier, Neil C. Thomson +3 more
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606 Citations1990Elizabeth F. Juniper, Patricia A. Kline +4 more
Regular, prolonged use of inhaled steroid can produce marked improvements in airway hyperresponsiveness, sometimes with full resolution, and these improvements are accompanied by clinically significant improvements in clinical asthma.
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538 Citations1992Peter K. Jeffery, RW Godfrey +4 more
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CHEST JournalNational Trends in the Morbidity and Mortality of Asthma in the US
515 Citations1987Richard Evans, Daniel I. Mullally +6 more
There has been a marked increase in hospitalization rates for asthma, a moderate increase in death rates from asthma and a smaller increase in overall prevalence of the disease in the United States.
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494 Citations1987D W Cockcroft, K.Y. Murdock
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476 Citations1987John G. Kirby, Frederick E. Hargreave +2 more
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475 Citations1986John Murray, André Bernard Tonnel +6 more
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465 Citations1990Ratko Djukanović, John Wilson +6 more
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455 Citations1985J Kraan, G H Koëter +3 more
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452 Citations1992David Cheung, Mieke Timmers +4 more
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425 Citations1987K. F. Kerrebijn, E VANESSENZANDVLIET +1 more
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350 Citations1992Brian O’Connor, Sarah L. Aikman +1 more
This randomized, double-blind, crossover study investigated whether tolerance develops to the protective effect of inhaled terbutaline on airway responsiveness to the bronchoconstrictors methacholine and AMP during sustained treatment with terbutalin.
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326 Citations1988M Turner‐Warwick
Current use of existing medication alone may not eliminate the problem of nocturnal asthma, and new drugs and/or new dosing strategies may be needed to control this disabling symptom completely.
ThoraxAsthma and irreversible airflow obstruction.
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It is concluded that asthma alone can cause irreversible airflow obstruction and that the degree of obstruction is a function of the duration and severity of previous asthma, and the possibility that reversible airflow obstruction in asthma may be preventable by minimising the degreeof persistent asthma is suggested.
American Review of Respiratory DiseaseAirways Inflammation in Nocturnal Asthma
296 Citations1991Richard J. Martin, Lisa Cicutto +3 more
TheNocturnal worsening of asthma has an associated cellular inflammatory response that is not seen in patients without overnight decrements in lung function, and this inflammatory response together with epithelial damage may be important factors in the etiology of nocturnal asthma.
Journal of Clinical InvestigationEffect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients.
296 Citations1976J Orehek, J P Massari +3 more
The present results demonstrate that very low levels of NO2 can adversely affect some asthmatics and could be related to any physical or clinical characteristics of the subjects tested.
American Review of Respiratory DiseaseInflammatory Cells and Eosinophilic Activity in Asthmatics Investigated by Bronchoalveolar Lavage: The Effects of Antiasthmatic Treatment with Budesonide or Terbutaline
295 Citations1990E Ädelroth, L Rosenhall +3 more
The increase in numbers of eosinophils seems less important than their activity, here measured as release of one degranulation product, ECP, while ECP levels in serum and BAL were significantly correlated.
New England Journal of MedicineNeutrophil Chemotactic Activity in Antigen-Induced Late Asthmatic Reactions
289 Citations1982Lajos Nagy, TH Lee +1 more
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American Review of Respiratory DiseaseThe Diagnosis of Mild Emphysema: Correlation of Computed Tomography and Pathology Scores
284 Citations1990Kazuyoshi Kuwano, Kenichi Matsuba +7 more
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American Review of Respiratory DiseaseImmediate and Late Airway Response of Allergic Rhinitis Patients to Segmental Antigen Challenge: Characterization of Eosinophil and Mast Cell Mediators
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American Review of Respiratory DiseaseLeukocytes and Mediators in Bronchoalveolar Lavage during Allergen-induced Late-phase Asthmatic Reactions
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The hypothesis that eosinophils and their products play a role in tissue injury in LPR and that eOSinophil infiltration may be associated with macrophage activation is supported.
CHEST JournalBronchoalveolar Lavage of Allergic Asthmatic Patients following Allergen Bronchoprovocation
275 Citations1986W. James Metzger, Hal B. Richerson +3 more
The studies show that in carefully selected, mildly symptomatic asthmatic subjects, BPC and BAL may be useful to evaluate pathogenetic mechanisms in allergic bronchial asthma.
New England Journal of MedicineMethotrexate in the Treatment of Corticosteroid-Dependent Asthma
264 Citations1988Michael F. Mullarkey, Brent A. Blumenstein +4 more
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CHEST JournalInternational Trends in Asthma Mortality: 1970 to 1985
263 Citations1988Rodney Jackson, Malcolm R. Sears +2 more
Recent international trends in asthma mortality among people aged five to 34 years were examined as a follow-up to an epidemic of asthma deaths in the late 1970s which appeared to be confined to New Zealand.
American Review of Respiratory DiseaseEvidence for Elevated Levels of Histamine, Prostaglandin D2, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma
252 Citations1990Mark C. Liu, Eugene R. Bleecker +7 more
Elevated levels of multiple mediators with potent bronchoconstricting activity are present in the airways of subjects with mild asthma, indicating that even mild disease is associated with evidence of airway inflammation.
Journal of Allergy and Clinical ImmunologyRelease of leukotrienes in patients with bronchial asthma
251 Citations1988Stephen C.-T. Lam, Henry Chan +3 more
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British Journal of PharmacologyInhibition of IgE‐dependent histamine release from human dispersed lung mast cells by anti‐allergic drugs and salbutamol
250 Citations1987Martin K. Church, Jun Hiroi
The results suggest that salbutamol is a more effective inhibitor of mediator release from human lung mast cells than anti‐allergic drugs, and both sal butamol and SCG are likely to be effective inhibitors of both preformed and newly generated mediators.
BMJBronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction.
248 Citations1985K C Flint, K.B.P. Leung +4 more
Bronchoalveolar lavage performed in patients with extrinsic asthma and 14 controls yielded similar recoveries of fluid and cells, but mast cells and eosinophils formed a greater proportion of the cells recovered from the asthmatic subjects, suggesting that they are likely to be important in the pathogenesis of airflow obstruction in asthma.
American Review of Respiratory DiseaseCharacteristics of the Inflammation in Biopsies from Large Airways of Subjects with Asthma and Subjects with Chronic Airflow Limitation
238 Citations1992Suzanne Ollerenshaw, Ann J. Woolcock
There was a significant increase in the number of lymphocytes, eosinophils, and mast cells in the asthmatic airways, particularly in the lamina propria, compared with the CAL subjects.
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232 Citations1991Ole D. Wolthers, S Pedersen
Treatment with inhaled budesonide is associated with a dose related suppression of short term linear growth in children with mild asthma.
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223 Citations1987Thomas B. Casale, Donald K. Wood +5 more
Allergic asthmatics have ongoing lung mast cell degranulation that might contribute to the etiology of airway hyperresponsiveness, according to a sensitive single isotope enzymatic assay.
American Review of Respiratory DiseaseInhaled Corticosteroids Reduce the Severity of Bronchial Hyperresponsiveness in Asthma, But Oral Theophylline Does Not
215 Citations1987Jacqueline I. DuToit, Cheryl M. Salome +1 more
Aerosol steroids, rather than theophylline, are the treatment of choice when reduction in the severity of BHR is the aim of treatment in patients with severe asthma.
Journal of Allergy and Clinical ImmunologyCandidiasis and dysphonia complicating beclomethasone treatment of asthma
213 Citations1980J.H. Toogood, Barbara Jennings +2 more
Although dysphonia and thrush were both related to beclomethasone usage, they did not appear to be directly related to one another, and they required different treatments (voice rest and nystatin), they need not preclude the long-term use of beclometrichasone, even in high dosage when required.
Journal of Allergy and Clinical ImmunologyIncreased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitization to salbutamol
194 Citations1990C.P. van Schayck, Sietze J. Graafsma +4 more
It was concluded that long-term use of salbutamol caused a small but significant increase in bronchial hyperresponsiveness (BHR), and this increase was not caused by subsensitization of beta 2-adrenoceptors to sal butamol.
Journal of Clinical InvestigationCold Urticaria
187 Citations1977Stephen I. Wasserman, Nicholas A. Soter +1 more
Sera obtained from the venous effluents of cold-challenged arms of patients with idiopathic cold urticaria without plasma or serum cryoproteins exhibited increased neutrophil chemotactic activity without alterations of the complement system, and this active principle exhibited a time-course of release that could be superimposed upon that of histamine and the low molecular-weight eosinophil Chemotactic factor.
American Review of Respiratory DiseaseUse and Misuse of Metered-dose Inhalers by Patients with Chronic Lung Disease: A Controlled, Randomized Trial of Two Instruction Methods
185 Citations1989Patricia de Blaquiere, Dale B. Christensen +2 more
A group of four variables predicted correct metered-dose inhaler use: bronchodilator responsiveness, a history of additional about proper technique, verbal knowledge of the correct inhaler maneuvers, and the patient's perception of whether it is important to use an inhaler.
American Review of Respiratory DiseaseSpectrum of Prostanoid Release after Bronchoalveolar Allergen Challenge in Atopic Asthmatics and in Control Groups: An Alteration in the Ratio of Bronchoconstrictive to Bronchoprotective Mediators
183 Citations1989Sally E. Wenzel, Jay Y. Westcott +2 more
A significant positive correlation was found between histamine, PGD2, and TX levels after challenge among all groups, and there were no significant changes among the four groups after allergen challenge in 6-keto-PGF1 alpha or PGE2.
BMJPurpura and dermal thinning associated with high dose inhaled corticosteroids.
183 Citations1990Simon Capewell, Sarah Reynolds +3 more
Skin thinning and purpura represent further evidence of systemic effects of high dose inhaled corticosteroids in patients receiving treatment for chest diseases.
American Review of Respiratory DiseaseTime Course of Change in Bronchial Reactivity with an Inhaled Corticosteroid in Asthma
182 Citations1991A.S. Vathenen, Alan J. Knox +2 more
Symptom scores and beta 2-agonist inhaler use were lower in the budesonide group than the placebo group during treatment but tended to be similar or higher in the 2 wk following cessation of treatment.
ThoraxDysphonia caused by inhaled steroids: recognition of a characteristic laryngeal abnormality.
174 Citations1983Alexander Williams, M S Baghat +4 more
Nine of 14 asthmatic patients who presented with persistent dysphonia while taking inhaled corticosteroids had a bilateral adductor vocal cord deformity with bowing of the cords on phonation, which causes the dysphonia and usually occurs without candidiasis.
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168 Citations1984Paula Fernanda Rivero Díaz, F Galleguillos +3 more
The results suggest that the efficacy of DSCG in bronchial asthma might be related to its ability to suppress the local accumulation of eosinophils and specific-IgE antibodies.
New England Journal of MedicineRelease of Mast-Cell Mediators and Alterations in Lung Function in Patients with Cholinergic Urticaria
168 Citations1980Nicholas A. Soter, Stephen I. Wasserman +2 more
These observations extend to the lungs the manifestations of a condition previously thought to be restricted to the skin, which is similar to those recognized in other skin disorders dependent on mast cells.
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166 Citations1991E.M. Pouw, Mark F. Prummel +3 more
Multiple choi.ce paper General topics relating to cardiopulmonary resuscitation and practical examination Extcrnal cardiac massage and mouth to mouth ventilation.
New England Journal of MedicineExercise-Induced Late Asthmatic Reactions with Neutrophil Chemotactic Activity
161 Citations1983TH Lee, Toshikazu Nagakura +3 more
It is suggested that some patients with exercise-induced asthma have late reactions that, as in the case of antigen-induced bronchoconstriction, are accompanied by the release of neutrophil chemotactic activity.
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160 Citations1987Thomas B. Casale, Donald K. Wood +4 more
The data suggest that when allergic asthmatics are exposed to relevant antigens they have in vivo lung mast cell degranulation which results in airway constriction and contributes to nonspecific airway hyperresponsiveness.
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155 Citations1992Steve N. Georas, Mark C. Liu +4 more
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154 Citations1988J Kraan, G H Koëter +5 more
In a double-blind study of 2 parallel groups of 15 allergic asthmatic patients each, treatment with inhaled budesonide has a dose- and time-dependent effect on the degree of bronchial hyperreactivity.
The LancetNOCTURNAL ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN TAKING INHALED BECLOMETHASONE DIPROPIONATE
154 Citations1986Catherine Law, J W Honour +3 more
Children receiving inhaled BDP had lower cortisol secretion during the night than those who were not taking inhaling BDP, a delayed rise from the nocturnal nadir, and low early morning levels.
American Review of Respiratory DiseaseElevated Bronchoalveolar Lavage Fluid Histamine Levels in Allergic Asthmatics Are Associated with Increased Airway Obstruction
152 Citations1991Nizar N. Jarjour, William J. Calhoun +2 more
Asthmatics and patients with allergic rhinitis had significantly higher BAL fluid histamine than did normal subjects and levels of tryptase and histamine in BAL were not correlated with FEV1 percent predicted in the asthmatic group.
ThoraxEffects of long term inhaled high dose beclomethasone dipropionate on adrenal function.
152 Citations1983Michael J. Smith, Mark E. Hodson
Patients taking more than 1500 micrograms/day of inhaled beclomethasone may require systemic corticosteroids during prolonged stress.
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151 Citations1960James W. Messer, Gustavus A. Peters +1 more
This paper summarizes the data obtained in a review of all cases in which the clinical diagnosis of bronchial asthma was made at the Mayo Clinic during the 40-year period 1916 through 1955 and in which necropsy was performed.
Journal of Allergy and Clinical ImmunologyReduction of budesonide after a year of increased use: A randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained
146 Citations1991Elizabeth F. Juniper, Patricia A. Kline +2 more
It was demonstrated recently that 1 year of regular inhaled budesonide use can produce substantial improvements in airway responsiveness accompanied by significant improvements in clinical asthma severity, and the present study was designed to evaluate whether these improvements are maintained when the dose of budesonides is reduced.
The LancetRandomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma
144 Citations1990Robert J. Shiner, Andrew Nunn +2 more
After 24 weeks of treatment the prednisolone dose had been reduced by a significantly greater proportion in the methotrexate than in the placebo group and the reduction was not sustained after the study treatment stopped.
CHEST JournalInflammatory Markers in Bronchoalveolar Lavage and in Bronchial Biopsy in Asthma during Remission
140 Citations1990Antonio Foresi, Giuseppina Bertorelli +3 more
In the asthmatic group, the degree of bronchial responsiveness correlated with ciliated cells in BAL and with intra-epithelial cells in BB, and inflammatory changes withinBronchoalveolar lavage and BB may be linked to the development of Bronchial hyperresponsiveness.
DrugsBudesonide A Preliminary Review of its Pharmacodynamic Properties and Therapeutic Efficacy in Asthma and Rhinitis
130 Citations1984Stephen P. Clissold, R.C. Heel
Budesonide has been shown to offer an effective alternative to oral or other inhaled corticosteroids in the management of asthma and rhinitis, however, its relative efficacy and tolerability during long term use, compared with beclomethasone dipropionate, remains to be clarified.
ThoraxEffect of prednisone and beclomethasone dipropionate on airway responsiveness in asthma: a comparative study.
128 Citations1988Christine Jenkins, Ann J. Woolcock
At doses that had similar beneficial effects on lung function beclomethasone dipropionate caused a significant improvement in bronchial hyperresponsiveness whereas prednisone caused no change.
American Review of Respiratory DiseaseThe Effect of Inhaled Corticosteroids on the Maximal Degree of Airway Narrowing to Methacholine in Asthmatic Subjects
126 Citations1991Elisabeth H. Bel, Mieke Timmers +3 more
The effects of inhaled budesonide on the maximal response plateau of the dose-response curve to inhaled methacholine in mildly asthmatic patients in whom a raised plateau could be measured were studied.
BMJCircumstances of death from asthma.
126 Citations1984Annette J. Johnson, Andrew Nunn +3 more
Detailed review of the circumstances of 90 deaths from asthma showed that a few were inevitable but that in the remainder four main sets of circumstances in the fatal attack contributed to the death.
BMJAsthma mortality: comparison between New Zealand and England.
125 Citations1986Malcolm R. Sears, H H Rea +5 more
New Zealand had an apparently higher rate of non-preventable deaths from asthma, suggesting a greater severity of asthma in New Zealand, and many characteristics of patients and management, including poor compliance with treatment and deficiencies in long term and emergency care were qualitatively similar in the two countries.
American Review of Respiratory DiseaseModulation of Neurogenic Inflammation by Neutral Endopeptidase
122 Citations1991Jay A. Nadel, D. B. Borson
It is suggested that decreased NEP activity will result in exaggerated neurogenic inflammation and may play an important role in inflammatory diseases in airways and drugs that cause up-regulation of NEP may play a therapeutic role by suppressing neurogenic responses.
JAMAChanging patterns of asthma mortality. Identifying target populations at high risk
119 Citations1990Kevin B. Weiss
Annals of Internal MedicineLack of Benefit of Methotrexate in Severe, Steroid-Dependent Asthma
117 Citations1991Serpil C. Erzurum, Jonathan Leff +5 more
The study does not support the use of methotrexate in the treatment of severe asthma, and no significant benefit of metotrexate on asthma control could be shown.
ThoraxMorphological integrity of the bronchial epithelium in mild asthma.
112 Citations1990S Lozewicz, Clive Wells +5 more
Findings indicate that airway hyperresponsiveness may be present when there is no apparent change in the structure of the bronchial epithelium, as well as when there are no differences between the asthmatic and healthy groups.
American Review of Respiratory DiseaseLate-phase Asthmatic Reaction to Inhaled Allergen Is Associated with Early Recruitment of Eosinophils in the Airways
109 Citations1991Giovanni A. Rossi, Emanuele Crimi +5 more
It is concluded that the development of the late-phase asthmatic response to allergen inhalation challenge and the allergenic-induced increase in airway responsiveness are associated with an early recruitment of eosinophils in the airways.
The Journal of ImmunologyA histamine-releasing factor from activated human mononuclear cells.
106 Citations1985Allen P. Kaplan, Mary Haak‐Frendscho +3 more
Rec reproducible methods for histamine-releasing factor production in large quantities are developed by using cells obtained from leukapheresis packs, by detection utilizing donor basophils known to release well with anti IgE, and by quantitation of histamine by the radioenzyme method.
American Review of Respiratory DiseaseNeuropeptides and Asthma
105 Citations1991Peter J. Barnes
Neuropeptides that are found in sensory nerves, such as substance P, neurokinin A, and calcitonin gene-related peptide, have inflammatory effects and might also contribute to the pathology of asthma if released from sensory nerve endings by an axon reflex.
Journal of Allergy and Clinical ImmunologyAerosolized terbutaline in asthmatics: development of subsensitivity with long-term administration
104 Citations1982Richard W. Weber, John A. Smith +1 more
Both peak response and duration of action decreased significantly between TI and TII and Cumulative dose-response curves showed that further improvement occurred after each inhalation during TI but that there was significant improvement only after the first inhalations during TII.
DrugsBeclomethasone Dipropionate A Reappraisal of its Pharmacodynamic Properties and Therapeutic Efficacy After a Decade of Use in Asthma and Rhinitis
101 Citations1984Rex N. Brogden, R.C. Heel +2 more
It is confirmed that inhaled beclomethasone dipropionate 400 to 800μg daily can reduce the need for oral maintenance corticosteroids in the majority of asthmatic patients requiring such therapy, and that increasing the dosage to 2000 μg daily may provide additional clinical benefit in some patients unresponsive to usual therapeutic dosages.
American Review of Respiratory DiseaseIdentification of an Alveolar Macrophage-derived Activity in Bronchial Asthma that Enhances Leukotriene C4 Generation by Human Eosinophils Stimulated by lonophore A23187 as a Granulocyte-macrophage Colony-stimulating Factor
94 Citations1989C. J. Howell, J-L. Pujol +5 more
Incubation of eosinophils with alveolar macrophage supernatants isolated from asthmatic subjects followed by stimulation with the calcium ionophore A23187 resulted in enhancement of the capacity of EOS to elaborate leukotriene C4 (LTC4) (mean enhancement 169 +/- 37%, n = 31).
Journal of Applied PhysiologyAllergen-induced increase in airway responsiveness and inflammation in mild asthma
94 Citations1990Vito Brusasco, Emanuele Crimi +3 more
It is concluded that, in stable asymptomatic asthma, baseline airway responsiveness does not correlate with the presence in the airways of inflammatory and immunoeffector cells that can be recovered by BAL, and the allergen-induced increase inAirway responsiveness is associated with an influx of eosinophils and lymphocytes in the bronchial lumen.
Journal of Allergy and Clinical ImmunologyMethotrexate in the treatment of steroid-dependent asthma
93 Citations1991Philip D. Dyer, Tracy Vaughan +1 more
Low-dose MTX significantly reduced the steroid requirement in this group of subjects with steroid-dependent asthma, and this reduction in steroid requirement was obtained without altering clinical status and without significant complication.
BMJInflammatory cells in the airways in mild asthma.
90 Citations1988S Lozewicz, E. Gómez +2 more
Les biopsies de the membrane muqueuse bronchique montrent chez les malades un exces de mastocytes dans the lamina propria et une augmentation des nombres d'eosinophiles, mais cette derniere difference n'est pas statistiquement significative.
CHEST JournalBronchoalveolar Lavage and Morphology of the Airways after Cessation of Exposure in Asthmatic Subjects Sensitized to Toluene Diisocyanate
89 Citations1990Pierluigi Paggiaro, Elena Bacci +7 more
It is suggested that persistent NSBH in TDI asthma after cessation of work may be related to an inflammatory reaction in which eosinophil infiltration seems to be a major determinant.
Journal of Allergy and Clinical ImmunologyInhalation challenge and pharmacologic studies of toluene diisocyanate (TDI)—sensitive workers
88 Citations1979Brian T. Butcher, Reynold M. Karr +5 more
TDI reactors gave decreased lymphocyte cAMP dose response slopes to stimulation with isoproterenol, prostaglandin E1, and TDI, which suggests that impairment of adrenergic receptors may play an important role in TDI reactivity.
Journal of Allergy and Clinical ImmunologyAn open study of Auranofin in the treatment of steroid-dependent asthma
85 Citations1988David I. Bernstein, Jonathan A. Bernstein +2 more
To determine the efficacy of oral gold in asthma, 20 patients with steroid-dependent asthma received auranofin at a dose of 3 mg by mouth, twice daily, in a 24-week open clinical trial.
CHEST JournalAssessment of Tachyphylaxis following Prolonged Therapy of Asthma with Inhaled Albuterol Aerosol
85 Citations1984Lawrence H. Repsher, John A. Anderson +7 more
It is felt that clinically significant tachyphylaxis to inhaled albuterol aerosol must be quite unusual and that chronic therapy with inhaledAlbuterl aerosol is probably both safe and efficacious for bronchospastic disorders.
American Review of Respiratory DiseaseFour-times-a-day Dosing Frequency Is Better than a Twice-a-day Regimen in Subjects Requiring a High-dose Inhaled Steroid, Budesonide, to Control Moderate to Severe Asthma
83 Citations1989Jean-Luc Malo, André Cartier +5 more
The maximal daily swings in peak expiratory flow rates were slightly greater in the BID group, although this difference was not physiologically significant, and Spirometry, cortisol secretion, and the response after synthetic ACTH injection were not significantly different in either group.
Journal of Allergy and Clinical ImmunologyParadoxical bronchospasm associated with the use of inhaled beta agonists
81 Citations1990Richard A. Nicklas
Patients who report that an inhaled beta-adrenergic agonist makes their asthma worse, as well as the patients who fail to demonstrate expected improvement with this form of therapy, should be suspected of having developed paradoxical bronchospasm.
American Review of Respiratory DiseaseHigh Doses of Inhaled Corticosteroids in Unstable Chronic Asthma: A Multicenter, Double-blind, Placebo-controlled Study
79 Citations1989Sergio Salmeron, Jean‐Claude Guérin +5 more
It is concluded that, in chronic asthma, inhaled BDP 1,500 micrograms/day maintains the optimal pulmonary function in addition to the clinical benefit induced by a short course of oral corticosteroids.
Journal of Allergy and Clinical ImmunologyAsthma and mast cell activation
72 Citations1989Michael Kaliner
Understanding pathophysiologic events in asthma will be useful in formulating therapy, and a relationship between MCA and the histamine-induced release of the sensory neuropeptide substance P, which causes vasodilation is indicated.
Journal of Allergy and Clinical ImmunologyA comparison of the effects of sedium cromoglycate and beclomethesone dipropionate on pulmonary function and bronchial hyperreactivity in subjects with asthma
69 Citations1987U GERNERSVENDSEN, L. Frelund +4 more
SCG was most effective when it was used as the first drug, indicated by a significant increase in FVC in the first period (p less than 0.05) and the total effect on logarithm-natural (Ln) (PC20), i.e., the mean effects of the two periods, was also significant.
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