Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.
Proceedings of the National Academy of SciencesPublished 15 April 1991Open access
Rocco J. Rotello, Rita Lieberman, A F Purchio, L. E. Gerschenson
Citations275
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TL;DR
Two biological actions of transforming growth factor beta 1 are described in primary cultures of rabbit uterine epithelial cells, suggesting that proliferation and apoptosis together comprise normal cell growth regulation.
Abstract
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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