Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons
Brain ResearchPublished 1 August 1987
Elliott J. Mufson, A.D. Kehr, Bruce H. Wainer, M.‐Marsel Mesulam
Citations53
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers, which is irreversible for at least 6 months and has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholineceptive neurons.
Abstract
Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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