MOUSE BRAIN TYROSINE HYDROXYLASE AND GLUTAMIC ACID DECARBOXYLASE FOLLOWING TREATMENT WITH ADRENOCORTICOTROPHIC HORMONE, VASOPRESSIN OR CORTICOSTERONE
Journal of NeurochemistryPublished 1 October 1978
Adrian J. Dunn, Nancy Gildersleeve, Harry Gray
Citations43
SJR quartileQ1
SJR score1.50
SNIP1.02
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TL;DR
No changes in the activity of either TH or GAD were observed in any brain region following repeated administration of adrenocorticotrophic hormone, lysine vasopressin or corticosterone, which suggests that the changes of catecholamine turnover are not mediated by changes of TH activity.
Abstract
Abstract The activities of tyrosine hydroxylase (TH) and glutamic acid decarboxylase (GAD) from several mouse brain regions were assayed following repeated administration of adrenocorticotrophic hormone (ACTH), lysine vasopressin (LVP) or corticosterone. Although similar treatments with ACTH have been shown to result in changes of catecholamine turnover and GABA content, no changes in the activity of either TH or GAD were observed in any brain region. Likewise LVP had no effect on either enzyme. Since the assays for TH were performed with concentrations of tyrosine and tetrahydrobiopterin cofactor below their respective Michaelis constants, this suggests that the changes of catecholamine turnover are not mediated by changes of TH activity. Twice daily corticosterone adrninistration for four days increased TH activity in the hypothalamus but not in any other brain region.
Keywords
PsychologyMedicineNeuroscience
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