Continuum of overlapping clones spanning the entire human chromosome 21q
NaturePublished 1 October 1992
Ilya Chumakov, Philippe Rigault, Sophie Guillou, Pierre Ougen, Alain Billaut, G Guasconi
Citations390
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction.
Abstract
A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and ends with subtelomeric loci of 21q. The resulting order of sequence-tagged sites is consistent with other physical and genetic mapping data. This set of overlapping clones will promote our knowledge of the structure of this chromosome and the function of its genes.
Keywords
Agricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
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