Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs
Brain ResearchPublished 1 July 1982
Joan P. Schwartz, John Pearson, Eugene M. Johnson
Citations162
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
It is concluded that NGF has two separate effects on sensory neurons: adult sensory neurons require NGF for normal function whereas developing neurons requireNGF for both survival and transmitter expression.
Abstract
Nerve growth factor (NGF) deprivation was produced in adult rats and guinea pigs by immunization against mouse NGF. Exposure of adult animals to anti-NGF had no effect on sensory ganglion neuronal number or size-frequency histograms. However, the substance P content of sensory ganglia, spinal cord and hind paw skin decreased to as great an extent as was seen in animals exposed to anti-NGF in utero. We conclude that NGF has two separate effects on sensory neurons: adult sensory neurons require NGF for normal function whereas developing neurons require NGF for both survival and transmitter expression.
Keywords
Neuroscience
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