Affective Disorders in First-Degree Relatives of Adolescent Onset Bipolars, Unipolars, and Normal Controls
Journal of the American Academy of Child & Adolescent PsychiatryPublished 1 January 1991Open access
Stan Kutcher, Peter Marton
Citations77
SJR quartileQ1
SJR score3.00
SNIP2.88
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TL;DR
First-degree relatives of bipolar probands were significantly more likely to have a bipolar illness than those of unipolar probands and normal controls and rates of un bipolar depression in first- Degree relatives of bipolars and unipolars were not significantly different.
Abstract
Two hundred and fifty-nine first-degree relatives of 23 adolescent bipolars (81 relatives); 26 unipolars (95 relatives); and 24 normal controls (83 relatives) were assessed for the presence of affective disorders, using the family history method. First-degree relatives of bipolar probands were significantly more likely to have a bipolar illness than those of unipolar probands (p = 0.03) and normal controls (p = 0.001). Rates of unipolar depression in first-degree relatives of bipolars and unipolars were not significantly different but differed significantly between bipolars and normals (p = 0.002) and unipolars and normals (p = 0.006). The implications of these findings for clinical work, diagnosis, and research in adolescents with affective disorders are discussed.
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PsychologyMedicineHealth Professions
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