Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation
New England Journal of MedicinePublished 18 May 2000Open access
John P. Kress, Anne S. Pohlman, Michael O’Connor, Jesse B. Hall
Citations2,911
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
In patients who are receiving mechanical ventilation, daily interruption of sedative-drug infusions decreases the duration of mechanical ventilation and the length of stay in the intensive care unit.
Abstract
In patients who are receiving mechanical ventilation, daily interruption of sedative-drug infusions decreases the duration of mechanical ventilation and the length of stay in the intensive care unit.
Keywords
PsychologyMedicine
Springer series in statisticsNonparametric Estimation from Incomplete Observations
45,533 Citations1992Edward L. Kaplan, Paul Meier
Journal of the Royal Statistical Society Series B (Statistical Methodology)Regression Models and Life-Tables
39,259 Citations1972D. R. Cox
Critical Care MedicineAPACHE II
13,694 Citations1985William A. Knaus, Elizabeth A. Draper +2 more
The form and validation results of APACHE II, a severity of disease classification system that uses a point score based upon initial values of 12 routine physiologic measurements, age, and previous health status, are presented.
Critical Care MedicineAPACHE II-A Severity of Disease Classification System
13,396 Citations1986William A. Knaus, Elizabeth A. Draper +2 more
The form and validation results of APACHE II, a severity of disease classification system, are presented, showing an increasing score was closely correlated with the subsequent risk of hospital death for 5815 intensive care admissions from 13 hospitals.
Journal of the American Statistical AssociationNonparametric Estimation from Incomplete Observations
7,727 Citations1958Edward L. Kaplan, Paul Meier
BMJControlled Sedation with Alphaxalone-Alphadolone
2,913 Citations1974Michael A. E. Ramsay, T.M. Savege +2 more
Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit and provided “light sleep,” allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.
CHEST JournalThe Use of Continuous IV Sedation Is Associated With Prolongation of Mechanical Ventilation
926 Citations1998Marin H. Kollef, Nat T. Levy +4 more
This study suggests that strategies targeted at reducing the use of continuous i.v. sedation could shorten the duration of mechanical ventilation for some patients.
American Journal of Respiratory and Critical Care MedicinePermissive Hypercapnia. How Permissive Should We Be?
440 Citations1994F. Feihl, Cyril Perret
Critical Care MedicineComplications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens
401 Citations1998Audrey Shafer
Continuous infusion midazolam provides effective sedation in the ICU with few complications overall, especially when the dose is titrated.
Critical Care MedicineContinuous infusion of haloperidol controls agitation in critically ill patients
261 Citations1994Richard R. Riker, Gilles L. Fraser +1 more
Continuous infusion of haloperidol effectively controls severe agitation in critically ill patients, reduces requirements for bolus administration of sedatives and nursing time lost to that task, and may facilitate ventilator weaning.
CHEST JournalPropofol vs Midazolam in Short-, Medium-, and Long-term Sedation of Critically III Patients
257 Citations1993Genís Carrasco, Ricard Molina +3 more
It is concluded that propofol is a sedative agent with the same safety, higher clinical effectiveness, and a better cost-benefit ratio than midazolam in the continuous sedation of critically ill patients.
Annals of Internal MedicineComplications of Intrahospital Transport in Critically III Patients
243 Citations1987Sidney S. Braman, STEVEN M. DUNN +2 more
American Journal of Respiratory and Critical Care MedicineUnplanned Extubations in the Adult Intensive Care Unit: A Prospective Multicenter Study
210 Citations1998Thierry Boulain
Simple measures should be adopted to minimize the incidence of UEX and its related complications: more vigilance during procedures at patients' bedsides, adequate sedation of agitated patients, strong fixation of the tracheal tube, particular attention paid to orally intubated patients, and daily reassessment of the possibility of weaning from the ventilator.
American Journal of Respiratory and Critical Care MedicineSedation of Critically Ill Patients During Mechanical Ventilation. A Comparison of Propofol and Midazolam
178 Citations1996John P. Kress, M F O'Connor +5 more
P had a faster, more reliable, wake-up time; assessments of time-to-awaken were objective and reproducible; time to sedation was not significantly different; V O2 decreased similarly with both.
Critical Care MedicineComparative study of propofol versus midazolam in the sedation of critically ill patients
177 Citations1996Carlos Chamorro, F. J. de Latorre +10 more
In this population of critically ill patients, propofol is an effective and safe alternative for sedation, with some advantages, such as short duration of action and high effectiveness over the conventional regimen with benzodiazepines and opiates.
Critical Care MedicineComparison of propofol and midazolam for sedation in intensive care unit patients
176 Citations1995Kevin P. Ronan, T. James Gallagher +2 more
Propofol was as safe and as efficacious as midazolam for continuous intravenous sedation and the quality of sedation was better in the propofol-treated group.
The Journal of Trauma: Injury, Infection, and Critical CareRisk, Cost, and Benefit of Transporting ICU Patients for Special Studies
165 Citations1988Matthew Indeck, SHERYL PETERSON +2 more
Prospective evaluation of 103 consecutive transports for diagnostic studies of 56 patients out of the Shock Trauma Unit over a 3-month period was done to document physiologic changes, the cost of each transport, and to assess whether the information gained was utilized to change patient management.
Intensive Care MedicineProspective evaluation of self-extubations in a medical intensive care unit
108 Citations1993T Vassal, N. G. D. Anh +4 more
Deliberate self-extubation, the most frequent type of incident could possibly be reduced by better sedation of agitated patients and accidental self- Extubation by better training of the nursing staff.
Critical Care MedicineSedation for the critically ill neurologic patient
105 Citations1995Marek A. Mirski, Birgitt Muffelman +2 more
The scientific basis for sedation of critically ill neurologic patients is reviewed by summarizing the distinct neurophysiologic disturbances present in this population and presenting the central nervous system effects of sedative agents to permit optimal drug therapy.
Intensive Care MedicineUse of sedatives, analgesics and neuromuscular blocking agents in Danish ICUs 1996/97
88 Citations1999B Christensen, L. P. Thunedborg
Sedatives and analgesics are widely used in patients requiring mechanical ventilation in Danish ICUs and NMBAs are only used in a few patients.
Critical Care MedicineFederal and nationwide intensive care units and healthcare costs: 1986–1992
88 Citations1994Neil A. Halpern, Larry Bettes +1 more
Critical Care MedicineContinuous infusion of lorazepam versus midazolam in patients in the intensive care unit
83 Citations1999Eleonora L. Swart, Robert J. M. Strack van Schijndel +2 more
Lorazepam is a useful alternative to midazolam for the long-term sedation of patients in the medical intensive care unit and provides easier management of the sedation level.
Life SciencesGABA in morphine analgesia and tolerance
54 Citations1985Subbiah P. Sivam, I.K. Ho
Drugs affecting various steps of GABA transmission exhibit analgesia in a variety of experimental models in animals; this analgesic response generally requires high doses of the drugs and does not appear to be opiate-like since the GABAergic analgesia is naloxone-insensitive and lacks dependence liability.
JAMAPermissive hypercapnia in acute respiratory failure
37 Citations1994A. Bidani
Extensive animal model data support the hypothesis that ventilator-driven alveolar overdistention can induce significant parenchymal lung injury and avoidance of alveolars overdistsention through pressure or volume limitation has significant support based on animal models and computer simulation.
Critical Care ClinicsThe Cost of Sedating and Paralyzing the Critically Ill Patient
26 Citations1995Eugene Y. Cheng
Educating ICU practitioners on cost issues and key indications for these drugs not only may help with cost containment in the ICU but also can improve patient care.
PubMedDrug usage patterns in the ICU: profile of a major metropolitan hospital and comparison with other ICUs.
6 Citations1991Gundlach Ca, Faulkner Tp +1 more
Identifying drug use patterns in ICUs--an area of potentially high drug use, risk, and cost--provides valuable information for P & T Committees as well as for medical staff quality assurance and usage evaluation functions.
