Involvement of macrophage migration inhibitory factor in the evolution of rat adjuvant arthritis
Arthritis & RheumatismPublished 1 May 1998
Michelle Leech, Christine N. Metz, Leilani L. Santos, Tina Peng, Stephen R. Holdsworth, Richard Bucala
Citations160
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TL;DR
An important role for MIF is demonstrated in the evolution of rat adjuvant arthritis, and anti-MIF treatment led to profound, dose-dependent inhibition of the adjUvant arthritis clinical score, paw swelling, and synovial lavage leukocyte numbers.
Abstract
These findings demonstrate an important role for MIF in the evolution of rat adjuvant arthritis.
Keywords
Immunology and MicrobiologyNeuroscience
ScienceMechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity
1,611 Citations1966Barry R. Bloom, Boyce Bennett
The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied and elaborated into the medium a soluble material capable of inhibiting migration of normal exudates.
NatureMIF as a glucocorticoid-induced modulator of cytokine production
1,150 Citations1995Thierry Calandra, Jürgen Bernhagen +6 more
The unexpected finding that low con-centrations of glucocorticoids induce rather than inhibit MIF production from macrophages is reported, identifying a unique counter-regulatory system that functions to control inflammatory and immune responses.
Arthritis & RheumatismTreatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α
1,038 Citations1993Michael J. Elliott, Ravinder N. Maini +9 more
Preliminary results support the hypothesis that TNF alpha is an important regulator in RA, and suggest that it may be a useful new therapeutic target in this disease.
NatureMIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
998 Citations1993J. Bernhagen, Thierry Calandra +7 more
Macrophage migration inhibitory factor (MIF) is identified as a major secreted protein released by anterior pituitary cells in response to LPS stimulation, and it is concluded that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock.
The Journal of Experimental MedicineThe macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor.
990 Citations1994Thierry Calandra, Jürgen Bernhagen +2 more
It is reported that cells of the monocyte/macrophage lineage are an important source of MIF in vitro and in vivo, and high levels of both preformed MIF protein and MIF mRNA in resting, nonstimulated cells are observed.
Proceedings of the National Academy of SciencesAnti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.
986 Citations1992Richard Williams, Marc Feldmann +1 more
The capacity of the antibody to reduce the clinical score, paw swelling, and the histological severity of disease even when injected after the onset of clinical arthritis was found, which has implications for possible modes of therapy of human arthritis.
Proceedings of the National Academy of SciencesAn essential regulatory role for macrophage migration inhibitory factor in T-cell activation.
669 Citations1996Michael Bacher, Christine N. Metz +7 more
It is reported that MIF plays an important regulatory role in the activation of T cells induced by mitogenic or antigenic stimuli and assigned a previously unsuspected but critical role for MIF in antigen-specific immune responses.
The Journal of Experimental MedicineALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES
498 Citations1971Carl Nathan, Manfred L. Karnovsky +1 more
Macrophage adherence, phagocytosis, spreading, motility, and direct hexose monophosphate oxidation were enhanced, while protein synthesis was unaffected, so antigen-stimulated lymphocytes secrete a factor or factors which enhance certain macrophage functions.
Proceedings of the National Academy of SciencesArthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.
457 Citations1985Willem van Eden, Joseph Holoshitz +4 more
It is concluded that autoimmune arthritis is probably caused by antigenic cross-reactivity, and an autoimmune disease may be triggered by structural mimicry between antigens in the environment and self-antigen in the individual.
Nature MedicineRegulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
447 Citations1997Seamas C. Donnelly, Chris Haslett +6 more
It is shown in alveolar cells from patients with ARDS that MIF augments pro-inflammatory cytokine secretion, anti-MIF significantly attenuates TNFα and IL-8 secretion and MIF overrides, in a concentration-related fashion, the anti-inflammatory effects of glucocorticoids.
BiochemistryPurification, Bioactivity, and Secondary Structure Analysis of Mouse and Human Macrophage Migration Inhibitory Factor (MIF)
404 Citations1994Jürgen Bernhagen, Robert A. Mitchell +4 more
These studies establish the biochemical identity of native and recombinant MIF and provide a first insight into the three-dimensional structural properties of this critical inflammatory mediator.
PubMedMigration inhibitory factor expression in experimentally induced endotoxemia.
283 Citations1997Michael Bacher, Andreas Meinhardt +9 more
The constitutive production of MIF by several cell and tissue types together with its rapid release from intracellular pools distinguishes MIF from other cytokines or hormonal mediators and significantly expands the physiological role of this unique counter-regulator of glucocorticoid action.
The Journal of Experimental MedicineThe Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat
269 Citations1997Hui Y. Lan, Michael Bacher +7 more
It is argued that blocking MIF activity may be of benefit in the treatment of human rapidly progressive glomerulonephritis, and suggested that MIF may be important in immune-mediated disease generally.
The Journal of Experimental MedicineAn essential role for macrophage migration inhibitory factor in the tuberculin delayed-type hypersensitivity reaction.
257 Citations1996Jürgen Bernhagen, Michael Bacher +5 more
The administration of neutralizing anti- MIF antibodies to mice inhibited significantly the development of DTH, thus affirming the central role of MIF in this classic immunological response.
The Journal of Experimental MedicineCHARACTERIZATION OF A LYMPHOCYTE FACTOR WHICH ALTERS MACROPHAGE FUNCTIONS
225 Citations1973Carl Nathan, Heinz G. Remold +1 more
The data suggests that the activating factor is the same as MIF and that, in vitro, macrophages respond to this substance with migration inhibition before they become sensitive to its activating influence.
Molecular MedicineLocalization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland
183 Citations1995Toshihiko Nishino, Jürgen Bernhagen +4 more
PubMedMacrophages activated as suspension cultures with lymphocyte mediators devoid of antigen become cytotoxic for tumor cells.
135 Citations1975W. H. Churchill, W F Piessens +2 more
UrologyEnhanced expression of macrophage migration inhibitory factor in prostatic adenocarcinoma metastases
133 Citations1996Katherine L. Meyer‐Siegler, Perry B. Hudson
The results show that the DD-PCR technique is applicable for the identification and cloning of human genes that exhibit enhanced expression in prostate cancer metastases and indicate the possibility that MIF production by prostate cancer cells plays a role in the development of metastases.
Cellular ImmunologyThe cellular basis of adjuvant arthritis
126 Citations1983Joel D. Taurog, Gregory P. Sandberg +1 more
The data support the hypothesis that adjuvant inoculation in the rat results in the induction of a unique subpopulation of T cells that initiate the inflammatory joint disease.
PubMedDe Novo renal expression of macrophage migration inhibitory factor during the development of rat crescentic glomerulonephritis.
117 Citations1996Hui Y. Lan, Wei Mu +7 more
Data provide the first demonstration that renal epithelial cells are a major source of MIF in both normal and diseased kidney and the up-regulation of Mif expression may play an important role in macrophage accumulation and progressive renal injury in rat crescentic glomerulonephritis.
The Journal of ImmunologyMacrophages Activated as Suspension Cultures with Lymphocyte Mediators Devoid of Antigen Become Cytotoxic for Tumor Cells
116 Citations1975W. Hallowell Churchill, Willy F. Piessens +2 more
Lymphocyte supernatants and antigen-free fractions of the supernatant induced comparable macrophage-mediated tumor cytotoxicity and treatment of activated macrophages with trypsin did not alter their cytotoxic capacity.
EndocrinologyChronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat.
107 Citations1992Nicholas J. Sarlis, H.S. Chowdrey +2 more
This model of chronic inflammatory stress clearly activates the ACTH drive despite increased corticosteroid feedback in the morning, resulting overall in chronically increased B secretion.
Inflammation ResearchMonoclonal antibodies and arthritis
54 Citations1990M. E. J. Billingham, C A Hicks +1 more
It is clear that CD4 positive T-lymphocytes have a major role in the induction of adjuvant arthritis and that interaction between CD4 and Ia bearing cells is important.
Clinical & Experimental ImmunologyAnti-neutrophil monoclonal antibody therapy inhibits the development of adjuvant arthritis
50 Citations1997Leilani L. Santos, Eric F. Morand +3 more
Depletion of circulating neutrophils prevented joint inflammation and synovial leucocyte influx in AA, suggesting a pivotal role for neutrophil in the effector phase of AA, which is T cell‐dependent.
Scandinavian Journal of RheumatologyRole of Macrophage-Like Synovial Lining Cells in Localization and Expression of Experimental Arthritis
30 Citations1995Peter L. E. M. van Lent, A. E. M. Holthuysen +4 more
The role of Macrophage-Like Synovial Lining Cells in Localization and Expression of Experimental Arthritis and the role of these cells in “cell reprograming” is investigated.
InflammationSuppression of Adjuvant Arthritis and Synovial Macrophage Inducible Nitric Oxide by N-iminoethyl-L-Ornithine, A Nitric Oxide Synthase Inhibitor
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Rheumatology InternationalPhagocytic synovial lining cells in experimentally induced chronic arthritis: down-regulation of synovitis by CL2MDP-liposomes
25 Citations1994Peter L. E. M. van Lent, L. A. M. Van Den Bersselaar +4 more
This study indicates that phagocytic synovial lining cells play an important role in propagating chronic synovitis and that CL2MDP-liposomes should be injected in the chronic and not in the early arthritic phase.
PubMedExacerbation of adjuvant arthritis by adrenalectomy is associated with reduced leukocyte lipocortin 1.
22 Citations1997Yuan Yang, Paul Hutchinson +2 more
Endogenous glucocorticoids modulate leukocyte expression of lipocortin 1 in inflammatory disease, and reduced lipocortsin 1 may be involved in the exacerbation of AA by adrenalectomy.
PubMedImmunohistochemical changes in synovial tissue during the course of adjuvant arthritis.
19 Citations1995Carme Pelegrı́, Àngels Franch +2 more
Few T lymphocytes (CD5+) were found in arthritic synovial membrane, whereas an increase of cells expressing CD8, CD4, CD25, Ia, and LCA was found, which are not evident in dexamethasone treated rats.
Annals of the Rheumatic DiseasesThe role of T cells in rheumatoid arthritis.
14 Citations1993Gary S. Firestein, Nathan J. Zvaifler
One of the major goals of the autocrine/paracrine model proposed in 1990 has been achieved-namely, to encourage people to think critically about the interpretation of data on soluble mediators in the joint.