Precancerous Lesions and Oral Cancer in the Elderly
Clinics in Geriatric MedicinePublished 1 August 1992
Sol Silverman
Citations22
SJR quartileQ2
SJR score1.03
SNIP1.07
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Improvement in prevention and control of oral cancer is critically important through reducing risks by avoiding tobacco and alcohol; recognizing and treating premalignant lesions; and early detection of developed oral cancers.
Abstract
Oral cancer is closely related to growing old, with over 95% of all cases occurring in individuals over age 40. In spite of advances in treatment, 5-year survival rates remain poor. Therefore, improvement in prevention and control of oral cancer is critically important. This can be accomplished through (1) reducing risks by avoiding tobacco and alcohol; (2) recognizing and treating premalignant lesions; and (3) early detection of developed oral cancers.
Keywords
DentistryMedicine
CancerThe Karnofsky performance status scale: An examination of its reliability and validity in a research setting
1,060 Citations1984Vincent Mor, Linda Laliberte +2 more
The utility of the Karnofsky Performance Status Scale as a valuable research tool when employed by trained observers is suggested and the relationship of the KPS to longevity in a population of terminal cancer patients documents its predictive validity.
Journal of Chronic DiseasesThe effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx
518 Citations1972Kenneth J. Rothman, Andrew Z. Keller
If smoking and drinking both are causes of oral cancer—as the data suggest—then the removal of both will be necessary to prevent a large proportion of the disease in males.
CancerLeukoplakia revisited.A clinicopathologic study 3256 oral leukoplakias
393 Citations1975Charles A. Waldron, William G. Shafer
There are regional differences in the incidence and character of leukoplakia in the United States and the Emory material, obtained almost exclusively from patients residing in the Southeastern United States, showed a proportionately higher total incidence, a lower male/female ratio, and a greater frequency of epithelial dysplasia.
CancerTobacco and alcohol consumption in relation to the development of multiple primary cancers
264 Citations1977Ernst L. Wynder, M Mushinski +1 more
The relationship between tobacco and alcohol consumption and the development of additional primary cancers of the upper alimentary tract is reviewed and results conflict regarding the effect exerted by the continuation of these habits after the first diagnosis.
The Journal of the American Dental AssociationStudies in oral leukoplakia: A preliminary report on the period pervalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients
246 Citations1968J. J. Pindborg, O Jolst +2 more
Among 248 patients with oral leukoplakia lesions, 214 were reexamined with a median observation period of 3.7 years and found under the conditions of the present study that the lesion had changed little in the past five years.
Journal of Maxillofacial SurgeryFollow-up studies in oral leukoplakia
237 Citations1977J Bánóczy
The tongue and the lips were the site of predilection for malignant transformation and for dysplasia in oral leukoplakia, and Candida albicans infection and the simultaneous existence of several aetiological factors seemed to play a role inmalignant transformation.
CancerIncidence of oral carcinoma in patients with leukoplakia of the oral mucosa
232 Citations1967Jerzy Einhorn, Jan Wersäll
There is no evidence the the incidence of oral carcinoma can be diminished by surgical removal of the leukoplakia but this does not mean that the operation should be abandoned, mainly for histologic diagnosis.
Oral Surgery Oral Medicine Oral PathologyOccurrence of epithelial dysplasia in oral leukoplakia
221 Citations1976J Bánóczy, A Csiba
The histologic material of 500 leukoplakia patients was analyzed in order to define the characteristics of epithelial dysplasia and to correlate the findings with the clinical data.
Oral Surgery Oral Medicine Oral PathologyObservations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia
183 Citations1972Harry H. Mincer, Sidney A. Coleman +1 more
Following-up study of fifty-six patients with sixty-seven oral lesions biopsied and diagnosed as showing moderate or marked epithelial dysplasia showed that these lesions may be cured surgically, may recur after removal, may increase in size or severity, may regress or disappear without surgical treatment, may remain static, or may undergo malignant transformation.
The LancetSECOND RESPIRATORY AND UPPER DIGESTIVE TRACT CANCERS AFTER ORAL CANCER
181 Citations1981BarryS. Tepperman, PeterJ. Fitzpatrick
All patients with mouth cancer should be examined regularly because of this high risk of new cancers, one-third of these being in the mouth.
CancerAnatomical site and size of 222 early asymptomatic oral squamous cell carcinomas.A continuing prospective study of oral cancer. II
177 Citations1976Arthur Mashberg, Harry Meyers
It is incumbent upon the clinician to biopsy all asymptomatic, persistent (14 days or more) mucosal aberrations in the high risk areas, especially those with erythroplastic components, regardless of size.
CancerThe role of drinking and smoking in mortality from cancer and other causes in male alcoholics
167 Citations1981Wolfgang Schmidt, Robert E. Popham
Heavy alcohol use per se increases the risk of cancer at certain sites, but it may not increase the overall risk of neoplastic disease, according to a prospective study of a sample of male alcoholics.
Oral Surgery Oral Medicine Oral PathologyA follow-up study of sixty-one oral dysplastic precancerous lesions in Indian villagers
136 Citations1977J. J. Pindborg, D. K. Daftary +1 more
In a 7-year follow-up study of 107 cases of oral epithelial dysplastic precancerous lesions in Indian villagers, 6.6 per cent were found to develop into carcinomas and clinical spontaneous regression occurred in 14.8 per cent.
CA A Cancer Journal for CliniciansAlcohol as a Primary Risk Factor in Oral Squamous Carcinoma
127 Citations1981Arthur Mashberg, Lawrence Garfinkel +1 more
Results indicate that drinkers of six or more WEs a day may be at greater risk than smokers of 40 or more cigarettes a day, and that beer and wine may be greater risk factors than whiskey in the development of oral cancer.
The Journal of the American Dental AssociationEpidemiologic and Demographic Update in Oral Cancer: California and National Data—1973 to 1985
126 Citations1990Sol Silverman, Meir Gorsky
There is a slight trend toward an improvement in earlier detection; however, about two-thirds of all oral cancers are advanced (Stage III and IV) at the time of diagnosis.
The Journal of the American Dental AssociationTobacco Usage in Patients with Head and Neck Carcinomas: A Follow-Up Study on Habit Changes and Second Primary Oral/Oropharyngeal Cancers
124 Citations1983Sol Silverman, Meir Gorsky +1 more
Reducing or discontinuing smoking appeared to have a beneficial effect on the development of multiple head and neck cancers, and there was an increased risk for multiple cancers in males, probably because of their larger amount of daily smoking.
CancerEpidemiologic investigation of multiple primary cancer of the upper alimentary and respiratory tracts. I.A retrospective study
103 Citations1969Ernest L. Wynder, Hideaki Dono +3 more
Patients who smoke heavily before developing cancer are more likely to develop second, primary tumors, and continued smoking after initial diagnosis or radiation therapy for the first primary is associated with an increased frequency of second primary tumors.
CancerSeparate primary carcinomas of the esophagus and head and neck region in the same patient
92 Citations1976William G. Cahan, El B. Castro +2 more
Patients with primary cancers of both the oral cavity, pharynx, larynx (OPL) and esophagus were studied at Memorial Sloan‐Kettering Cancer Center, giving valuable clues as to the oncogenic influence of environmental factors as well as cellular, organ, and also systemic susceptibility.
Oral Surgery Oral Medicine Oral PathologyLeukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935–1984
84 Citations1988Jerry E. Bouquot, L. H. Weiland +1 more
Mucosal carcinomas associated with leukoplakias appear to be smaller, more mature histologically, and more likely to be only superficially invasive; such carcinomas present with fewer metastases at diagnosis and provide a better prognosis than similar carcinomas not associated withLeukoplakia.
International Journal of Radiation Oncology*Biology*PhysicsCarcinoma of the floor of mouth: an analysis of treatment results and the sites and causes of failures
82 Citations1976Karen K. Fu, Allen S. Lichter +1 more
Treatment results and sites and causes of failures were reviewed in 153 patients with carcinoma of the floor of the mouth who were treated between January 1957 and December 1973 with radiation therapy alone, surgery alone, or a combination of both.
CancerLeukoplakia-associated multiple carcinomas in patients with tongue carcinoma
67 Citations1986Hitoshi Shibuya, Teruo Amagasa +4 more
A series of 522 patients with a diagnosis of squamous cell carcinoma or carcinoma in situ of the tongue were reviewed and followed and leukoplakia was found in 88 of these patients before and after the diagnosis of tongue carcinoma.
American Journal of RoentgenologyExternal and interstitial radiation therapy of carcinoma of the oral tongue. A review of 32 years' experience
60 Citations1976KK Fu, JW Ray +2 more
In 204 patients with squamous cell carcinoma of the oral tongue treated with radiation therapy, the most significant prognostic factors appeared to be the presence of neck lymph node metastasis on presentation and the status of the disease three months after treatment.
The Journal of the American Dental AssociationErythroplasia: the earliest sign of asymptomatic oral cancer
48 Citations1978Arthur Mashberg
This analysis confirms previous suppositions that persistent erythroplasia rather than leukoplakia, in high-risk sites of the oral cavity, is the earliest and predominant sign of oral carcinoma.
CancerFamilial cancer in the general population
41 Citations1977Samuel Albert, M A Child
In the course of collecting samples of human milk for the National Cancer Institute, family histories have been assembled since 1971, and there were significantly more observed than expected cancers in lineages with cancer of breast, ovary, skin, corpus uteri, stomach, rectum, lung and bronchus, or colon.
JAMAHead and Neck Cancer in Alcoholics
38 Citations1973Benjamin Kissin
Three thousand seven alcoholics were examined for head and neck abnormalities and interviewed about drinking, smoking, and dietary patterns and it was indicated the alcoholics had significantly more cancer cases than the controls.