Concise, asymmetric total synthesis of spirotryprostatin A
TetrahedronPublished 10 September 2004
Tomoyuki Onishi, Paul R. Sebahar, Robert M. Williams
Citations61
SJR quartileQ3
SJR score0.43
SNIP0.60
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Abstract
The structurally intriguing cell-cycle inhibitor spirotryprostatin A has been synthesized utilizing an azomethine ylide dipolar cycloaddition reaction as the key step. This pentacyclic alkaloid contains a prenylated tryptophan-derived oxindole moiety that has been created in a regiocontrolled and stereocontrolled manner in a single step.
Keywords
ChemistryMedicineBiochemistry, Genetics and Molecular Biology
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