Association of HTLV-III with Epstein-Barr Virus Infection and Abnormalities of T Lymphocytes in Homosexual Men
The Journal of Infectious DiseasesPublished 1 October 1986
Charles R. Rinaldo, Lawrence Kingsley, David W. Lyter, B. S. Rabin, Robert W. Atchison, Anne J. Bodner
Citations41
SJR quartileQ1
SJR score2.04
SNIP1.23
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TL;DR
The results suggest that the interaction of HTLV-III and EBV and their immunologic perturbations are significant in the natural history of this retrovirus infection in homosexual men.
Abstract
Homosexual men were studied for associations among human T-lymphotropic virus type III (HTLV-III) infection, Epstein-Barr virus (EBV) infection, and T cell abnormalities. The presence of IgG antibody to EBV capsid antigen and antibody to EBV early antigen was significantly associated with augmented counts of suppressor T cells in healthy HTLV-III-seronegative men. HTLV-III-seropositive asymptomatic subjects had significantly enhanced titers of antibody to EBV and lower ratios of helper to suppressor T cells compared with HTLV-III-seronegative homosexual men. Of three men who seroconverted to HTLV-III, two had a greater than fourfold increase in titer of IgG antibody to EBV capsid antigen after seroconversion. These results suggest that the interaction of HTLV-III and EBV and their immunologic perturbations are significant in the natural history of this retrovirus infection in homosexual men.
Keywords
Immunology and MicrobiologyAgricultural and Biological SciencesMedicine
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