The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study
DiabetologiaPublished 1 August 2002Open access
Debbie A. Lawlor, S. Ebrahim, George Davey Smith
Citations213
SJR quartileQ1
SJR score3.62
SNIP2.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The results suggest that poor infant nutrition is an important causal factor in the development of Type II diabetes and insulin resistance in later life.
Abstract
Leg length is an indicator of early childhood environmental circumstances, in particular of infant nutrition. These results suggest that poor infant nutrition is an important causal factor in the development of Type II diabetes and insulin resistance in later life.
Keywords
Medicine
DiabetologiaHomeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
31,449 Citations1985David R. Matthews, J P Hosker +4 more
The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Clinical ChemistryEstimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints
570 Citations1990G. Russell Warnick, Robert H. Knopp +2 more
Refinements in the estimation model did not substantially improve LDL estimation or concordance of risk classification, and the use of estimated LDL for risk classification based on the National Cholesterol Education Program Adult Treatment Panel cutpoints of 1.30 and 1.60 g/L was considered acceptable.
BMJBritish Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns.
531 Citations1981A. G. Shaper, Stuart Pocock +4 more
Alcohol intake and body mass index explained only a part of the striking differences between towns in mean blood pressure readings, and some important "town"factors remained unexplained.
Clinical ChemistryEnzyme immunoassay for intact human insulin in serum or plasma
524 Citations1993Lennart Andersen, Bo Dinesen +3 more
This two-site immunoassay uses two murine monoclonal antibodies that bind to two different epitopes on the insulin molecule to quantitation of intact insulin in human serum and plasma, giving results that are lower than those obtained by using a competitive radioimmunoASSay, both in normal individuals and in non-insulin-dependent diabetics.
Journal of Epidemiology & Community HealthEarly growth and abdominal fatness in adult life.
426 Citations1992Catherine Law, D.J.P. Barker +3 more
The tendency to store fat abdominally, which is known to increase the risk of cardiovascular disease and diabetes independently of obesity, may be a persisting response to adverse conditions and growth failure in fetal life and infancy.
International Journal of EpidemiologyLeg and trunk length at 43 years in relation to childhood health, diet and family circumstances; evidence from the 1946 national birth cohort
315 Citations2002Martha E. Wadsworth
Adult leg length is particularly sensitive to environmental factors and diet in early childhood because that is the period of most rapid leg growth, and may be associated with the effects of serious illness and parental separation because of the child's growing sensitivity to stressful circumstances.
Journal of Epidemiology & Community HealthLeg length, insulin resistance, and coronary heart disease risk: The Caerphilly Study
241 Citations2001George Davey Smith, R Greenwood +4 more
Leg length is the component of stature related to insulin resistance and coronary heart disease risk and the reported associations suggest that pre-adult influences are important in the aetiology of coronaryHeart disease and insulin resistance.
Diabetes CareHigh Prevalence of Type 2 Diabetes in All Ethnic Groups, Including Europeans, in a British Inner City
216 Citations2001Lisa Riste, Farida Khan +1 more
A surprisingly high prevalence of diabetes was found in Europeans, as previously established in Caribbeans and Pakistanis, although substantial preventive opportunities through small reversals of glucose distributions are the challenge.
Journal of Epidemiology & Community HealthAdult height and mortality in London: early life, socioeconomic confounding, or shrinkage?
169 Citations1995David A. Leon, George Davey Smith +2 more
The cause specific variation in the height-mortality association lends little support to the contention that impaired growth in childhood is a marker of general susceptibility to disease in adulthood.
American Journal of EpidemiologySex Differences in Risk Factors for Clinical Diabetes Mellitus in a General Population: A 12-Year Follow-up of the Finnmark Study
148 Citations1998I. Nj lstad, E. Amesen +1 more
Investigation of the associations among obesity, height, cardiovascular risk factors, and the incidence of clinical diabetes mellitus in the Norwegian population-based Finnmark Study found prediabetic women had a relatively more adverse metabolic risk profile as compared with nondiabetics of the same sex.
DiabetologiaHeight and glucose tolerance in adult subjects
117 Citations1991D. C. Brown, Christopher D. Byrne +7 more
An unexpected negative correlation was found between 120-min plasma glucose and height in both sexes and the negative relationship between height and glucose tolerance is a new epidemiological observation which has not been reported.
British Journal Of NutritionGrowth and Health
108 Citations1951Isabella Leitch
Wolbach, S. B. & Howe, P. R. (1933b).
Diabetes Research and Clinical PracticePrevalence of diabetes in a suburban population of Bangladesh
82 Citations1997Mohammed Abu Sayeed, M Zafirul Hussain +3 more
The study showed an increased prevalence of impaired glucose tolerance and non-insulin-dependent diabetes mellitus among the suburban population of Bangladesh and the excess risk was observed with increased age, higher BMI and short stature.
Acta DiabetologicaOsteoporosis in type II diabetes
77 Citations1987Giancarlo Isaia, Lucia Bodrato +4 more
Osteoporosis is a possible complication of type II diabetes and may appear even in the absence of its classical complications, and no significant difference could be discerned between patients on diet and those on drugs.
Annals of Human BiologyEarly influences on the secular change in adult height between the parents and children of the 1958 birth cohort
77 Citations1991Eva Alberman, H Filakti +3 more
The present account is of data available from the 1958 British national birth cohort and its follow-up to the age of 23 years and showed that the size of the difference was increased by increasing intrauterine growth rate, and falling paternal social class.
Diabetic MedicineWomen with a history of gestational diabetes of European and South Asian origin are shorter than women with normal glucose tolerance in pregnancy
43 Citations2000Eleni Κousta, Natasha Lawrence +5 more
The LancetSeparating in-utero and postnatal influences on later disease
43 Citations1999David Gunnell, George Davey Smith +4 more
Associations of birthweight with leg length and trunk length are similar and Childhood exposures rather than in-utero programming may underlie specific associations seen between leglength and mortality.
Diabetes and insulin action
7 Citations1997Paul McKeigue