Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection
New England Journal of MedicinePublished 4 April 1991Open access
Eric S. Daar, Tarsem Moudgil, Richard D. Meyer, David D. Ho
Citations841
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The rapid and spontaneous decline in the viral load suggests an effective immune response in the host that, if understood, may be used to combat AIDS.
Abstract
Although p24 core antigenemia and viral isolation have previously been described during primary HIV-1 infection, this report documents the large viral burden during the acute phase of infection. The rapid and spontaneous decline in the viral load suggests an effective immune response in the host that, if understood, may be used to combat AIDS.
Keywords
Immunology and MicrobiologyMedicine
CellHIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
1,517 Citations1990Jerome A. Zack, Salvatore J. Arrigo +4 more
A modification of the polymerase chain reaction method is used to demonstrate that HIV-1 DNA synthesis is initiated in infected quiescent T cells at levels comparable with those of activated T cells.
New England Journal of MedicineIsolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency Syndrome
1,108 Citations1985David D. Ho, T R Rota +8 more
It is suggested that HTLV-III is neurotropic, is capable of causing acute meningitis, is responsible for AIDS-related chronic meneditis and dementia, and may be the cause of the spinal-cord degeneration and peripheral neuropathy in AIDS andAIDS-related complex.
New England Journal of MedicineQuantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons
1,078 Citations1989David D. Ho, Tarsem Moudgil +1 more
New England Journal of MedicineCytotoxic T-Cell Immunity to Influenza
933 Citations1983Andrew J. McMichael, Frances Gotch +2 more
It is concluded that cytotoxic T cells play a part in recovery from influenza virus infection.
The LancetACUTE AIDS RETROVIRUS INFECTION
706 Citations1985D. A. Cooper, Prudence Maclean +7 more
The notion of an acute clinical, immunological, and serological response to infection with ARV which should be considered in the differential diagnosis of mononucleosis-like syndromes in groups at high risk for the development of AIDS is supported.
ScienceBiologic Features of HIV-1 That Correlate with Virulence in the Host
673 Citations1988Cecilia Cheng‐Mayer, Deborah Seto +2 more
The development of disease was found to be correlated with the emergence of HIV-1 variants that were more cytopathic in vitro as the disease progressed and that replicated more efficiently in a wide variety of different human cells.
Journal of VirologyDifferential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex
598 Citations1988M Tersmette, R E de Goede +6 more
Evidence was obtained that the high replication rate of syncytium-inducing isolates observed during primary isolation may be due to higher infectivity of these isolates, and the finding that only syncyTium- inducing isolates could be transmitted to the H9 cell line is compatible with thisHigher infectivity.
The LancetREPLICATIVE CAPACITY OF HUMAN IMMUNODEFICIENCY VIRUS FROM PATIENTS WITH VARYING SEVERITY OF HIV INFECTION
534 Citations1986Birgitta Åsjö, Jan Albert +5 more
The relation between severity of illness and in-vitro replication potential of the viruses suggests that in the course of an infection selection may occur for HIV variants that replicate efficiently in T4 cells.
The LancetEXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN (HIV-Ag) IN SERUM AND CEREBROSPINAL FLUID DURING ACUTE AND CHRONIC INFECTION
516 Citations1986Jaap Goudsmit, DeborahA. Paul +10 more
Its persistence or reappearance seems to correlate with clinical, immunological, and neurological deterioration, and the findings suggest that HIV-Ag appears early and transiently in primary HIV infection.
NatureHigh levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients
386 Citations1990Shen Pang, Yoshio Koyanagi +4 more
The results indicate that each of the three species of viral DNA are detectable in blood and brain of AIDS patients and that in autopsy samples from patients with HIV encephalitis there is a considerably higher proportion of unintegrated viral DNA.
Annals of Internal MedicinePrimary Human T-Lymphotropic Virus Type III Infection
336 Citations1985David D. Ho, M. G. SARNGADHARAN +4 more
Physicians should consider the possibility of primary HTLV-III infection when evaluating patients who belong to one of the risk groups for the acquired immunodeficiency syndrome and who have prolonged febrile illnesses.
Journal of VirologyBiology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo
297 Citations1984John Byrne, M B Oldstone
The results indicate that cloned CTL propagated in vitro for long periods of time can mediate a biologically relevant effect in vivo and should be of considerable value in defining the precise manner in which CTL bring about control of viral infection, analyzing lymphocyte trafficking, and the potential use of cloning CTL in immunotherapy against viral disease.
Journal of Medical VirologyIsolation of human immunodeficiency virus (HIV) from plasma during primary HIV infection
103 Citations1987Jan Albert, Hans Gaines +10 more
Human immunodeficiency virus has been isolated from plasma in 6 of 7 patients showing clinical symptoms of a primary HIV infection and the frequency of HIV isolations was similar to that of asymptomatic carriers.
The LancetHLA-RESTRICTED VIRUS-SPECIFIC CYTOTOXIC T-LYMPHOCYTE RESPONSES TO LIVE AND INACTIVATED INFLUENZA VACCINES
98 Citations1981FrancisA. Ennis, Yihua Qi +5 more
All three vaccines induced HLA-restricted T-lymphocyte responses specific for influenza A virus, and this CTL response was found in 28 of 30 volunteers who showed antibody responses and in 3 of 6 who did not develop antibodies.
