Morphine: Single-Dose Tolerance
SciencePublished 29 November 1968
Conan Kornetsky, George T. Bain
Citations72
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.
Abstract
Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.
Keywords
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