α-Methylnoradrenaline-induced hypotension in the nucleus tractus solitarii, of the rat: A localization study

The sites in the nucleus tractus solitarii in the rat medulla oblongata where ( − )-α-methyl-noradrenaline induced hypotension were determined using microinjections using microInjections found the most effective area was found to extend from +500 to −400 μm of the caudal tip of the area postrema.

Abstract

The sites in the nucleus tractus solitarii in the rat medulla oblongata where ( − )-α-methyl-noradrenaline induced hypotension were determined using microinjections. The most effective area was found to extend from +500 to −400 μm of the caudal tip of the area postrema (defined as zero plane). At these sites no effect was observed with the ( + ) stereoisomer of α-methylnoradrenaline or vehicle. Injections of ( − )-methylnordrenaline in adjacent structures were ineffective.