Interleukin 10 Blocks HIV Replication in Macrophages by Inhibiting the Autocrine Loop of Tumor Necrosis Factor α and Interleukin 6 Induction of Virus
AIDS Research and Human RetrovirusesPublished 1 October 1994
D Weissman, Guido Poli, Anthony S. Fauci
Citations152
SJR quartileQ3
SJR score0.55
SNIP0.43
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TL;DR
IL-10 blocked HIV-induced tumor necrosis factor alpha and interleukin 6 secretion and inhibited HIV replication in monocyte-derived macrophages (MDMs) and was correlated with a block in endogenous TNF-alpha and IL-6 secretion from HIV-infected MDMs.
Abstract
Human interleukin 10 is a pleiotropic cytokine capable of suppressing cytokine production from macrophages and T cells; in addition, it exerts complex regulatory effects on CD8+ T cells, natural killer cells, vascular endothelial cells, and B lymphocytes. Levels of IL-10 are elevated in HIV-infected individuals, suggesting that this cytokine may play a role in the suppression of T cell and monocyte/macrophage function typical of HIV disease. In this article, IL-10 blocked HIV-induced tumor necrosis factor alpha and interleukin 6 secretion and inhibited HIV replication in monocyte-derived macrophages (MDMs). The inhibition by IL-10 was correlated with a block in endogenous TNF-alpha and IL-6 secretion from HIV-infected MDMs.
Keywords
Immunology and MicrobiologyMedicine
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