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Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

The Journal of Cell BiologyPublished 31 May 1999Open access
Randy A. Hall, Richard T. Premont, Robert J. Lefkowitz
Citations322
SJR quartileQ1
SJR score3.36
SNIP1.52
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TL;DR

Heptahelical receptors, so called because of their conserved structure featuring seven α-helical transmembrane spans, mediate physiological responses to a remarkably diverse array of stimuli.

Abstract

Heptahelical receptors, so called because of their conserved structure featuring seven α-helical transmembrane spans, mediate physiological responses to a remarkably diverse array of stimuli. These include hormones, neurotransmitters, small peptides, proteins, lipids and ions, as well as sensory

Keywords

MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology