Mismatch Negativity: Different Water in the Same River
Audiology and NeurotologyPublished 1 January 2000
Terence W. Picton, Claude Alain, Leun J. Otten, Walter Ritter, André Achim
Citations582
SJR quartileQ2
SJR score0.58
SNIP0.95
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TL;DR
Improvements in the techniques for measuring the mismatch negativity and in the paradigms for eliciting it will be needed before the MMN can become clinically useful as an objective measurement of such disorders in individual patients.
Abstract
The mismatch negativity (MMN) is a frontal negative deflection in the human event-related potential that typically occurs when a repeating auditory stimulus changes in some manner. The MMN can be elicited by many kinds of stimulus change, varying from simple changes in a single stimulus feature to abstract changes in the relationship between stimuli. The main intracerebral sources for the MMN are located in the auditory cortices of the temporal lobe. Since it occurs whether or not stimuli are being attended, the MMN represents an automatic cerebral process for detecting change. The MMN is clinically helpful in terms of demonstrating disordered sensory processing or disordered memory in groups of patients. Improvements in the techniques for measuring the MMN and in the paradigms for eliciting it will be needed before the MMN can become clinically useful as an objective measurement of such disorders in individual patients.
Keywords
PsychologyNeuroscience
ScienceMeasuring the Accuracy of Diagnostic Systems
10,020 Citations1988John A. Swets
For diagnostic systems used to distinguish between two classes of events, analysis in terms of the "relative operating characteristic" of signal detection theory provides a precise and valid measure of diagnostic accuracy.
NatureHearing lips and seeing voices
6,130 Citations1976Harry McGurk, John MacDonald
The study reported here demonstrates a previously unrecognised influence of vision upon speech perception, on being shown a film of a young woman's talking head in which repeated utterances of the syllable [ba] had been dubbed on to lip movements for [ga].
Annals of Internal MedicineClinical Epidemiology: A Basic Science for Clinical Medicine.
3,508 Citations1991
Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
PsychophysiologyThe N1 Wave of the Human Electric and Magnetic Response to Sound: A Review and an Analysis of the Component Structure
3,342 Citations1987Risto Näätänen, Terence W. Picton
It is concluded that at least six different cerebral processes can contribute to the Nl wave of the human auditory evoked potential, and that they often last much longer than the true N1 components that they overlap.
The Journal of the Acoustical Society of America<i>Auditory Scene Analysis: The Perceptual Organization of Sound</i>
3,030 Citations1994Albert S. Bregman, Stephen McAdams
Acta PsychologicaEarly selective-attention effect on evoked potential reinterpreted
2,731 Citations1978Risto Näätänen, A.W.K. Gaillard +1 more
The ‘Hillyard effect’ was explained as being caused by a superimposition of a CNV kind of negative shift on the evoked potential to the attended stimuli rather than by a growth of the ‘real’ N 1 component of theevoked potential.
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1,062 Citations1999R. Näätänen, István Winkler
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The results showed that, in all cases, the negative wave elicited by the deviant stimuli showed the highest amplitudes over the right hemiscalp irrespective of the ear of stimulation or the direction of attention, and this asymmetric potential distribution could be attributed to the sum of activities of two sets of neural generators.
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Journal of Cognitive NeuroscienceA Source Analysis of the Late Human Auditory Evoked Potentials
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Results from studies aimed at localizing cerebral generators of MMN indicate that a major MMN source is located in the auditory cortex, and intracranial MMN recordings in animals suggest that at least in some species, MMN subcomponents also may be generated in the thalamus and hippocampus.
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688 Citations1998Marie Cheour, Rita Čėponiené +5 more
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Proceedings of the National Academy of SciencesRole of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.
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NatureAttentive novelty detection in humans is governed by pre-attentive sensory memory
649 Citations1994H Tiitinen, Patrick May +2 more
This work addresses novelty detection in humans both on a physiological and behavioural level, and shows how attentive novelty detection is governed by a pre-attentive sensory memory mechanism.
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608 Citations1982Risto Näätänen, Michael J. Simpson +1 more
The comparison of these brain-wave sequences to those elicited by the same stimuli in reading subjects led to the conclusion that in detection conditions, deviant stimuli elicit two overlapping sequences of brain events: exogeneous and endogeneous.
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Impaired behavioral discrimination of a rapid speech change (/dα/versus/gα/) was correlated with diminished magnitude of an electrophysiologic measure that is not dependent on attention or a voluntary response, indicating that some children's discrimination deficits originate in the auditory pathway before conscious perception.
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454 Citations1984R. Hari, Matti Hämäläinen +7 more
P Pitch deviance in a sequence of repetitive tone pips elicited magnetic evoked-response changes with a topography suggesting that a neuronal mismatch process to the deviant tones activates the primary auditory cortex.
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Results indicate that sensory memory mechanisms can be modulated by training on a more general level, and demonstrate that compared to non-musicians, musicians are superior in pre-attentively extracting more information out of musically relevant stimuli.
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444 Citations1993Risto Näätänen, Petri Paavilainen +3 more
In the present conditions of very strongly focused attention, the mismatch negativity component of the auditory event-related potential was elicited even by frequency change in the ignored input stream, and its amplitude was very similar to that of the MMN elicited by equivalent deviant stimuli (targets) in the attended input stream.
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Findings call into question the assertion that the auditory mismatch detection process and the associated MMN wave are wholly independent of attentional influence and provide evidence that the processing of stimuli in unattended channels can be attenuated or gated at an early sensory level under conditions of highly focused auditory selective attention.
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The effect of processing load on event-related brain potentials (ERPs) was investigated in an intermodal selective attention task in which subjects attended selectively to auditory or visual stimuli.
Neuroscience LettersSeeing speech: visual information from lip movements modifies activity in the human auditory cortex
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360 Citations1998Erich Schröger, Christian M. Wolff
It is argued that one important prerequisite for linking the neural mechanisms reflected in change-related brain waves to behavioral distraction effects may be regarded as fulfilled.
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The conscious perception of infrequent deviant sounds occurring in a series of frequent standard sounds may in part be based on the output of an obligatorily operating deviance detection system that fuses into an integrated mismatch signal that in turn may activate subsequent processes that result in the triggering of a motor response.
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359 Citations1995Stanley V. Catts, A.M. Shelley +5 more
The abnormal auditory sensory memory processing indicated by low mismatch negativity amplitude in the schizophrenic patients cannot be accounted for by neuroleptic medication status, and this findings implicate the auditory cortex in the pathophysiology of schizophrenia.
NeuroreportDevelopment of a memory trace for a complex sound in the human brain
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This result reflects a gradual 'sharpening' of sensory information encoded in the memory trace: the representation of the standard stimulus eventually became precise enough to enable the cortical change-detector mechanism to detect a slight different stimulus.
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355 Citations1993Nelson Cowan, István Winkler +2 more
For an MMN to be elicited in response to a change in tone frequency, the representation of the standard tone must be both (a) well-established as a standard in memory, and (b) in a currently active state.
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337 Citations1999István Winkler, Teija Kujala +8 more
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335 Citations1998Claude Alain, David L. Woods +1 more
Investigating the neural circuits of sensory memory using behavioral and electrophysiological measures of auditory processing in patients with unilateral brain damage to dorsolateral prefrontal cortex, posterior association cortex, or the hippocampus provides evidence of a temporal-prefrontal neocortical network critical for the transient storage of auditory stimuli.
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331 Citations1999Terence W. Picton, Claude Alain +6 more
Brain electric source analysis and variable-resolution electromagnetic tomography analyses showed that the dominant intracerebral sources for the late auditory-evoked potentials were in the supratemporal plane and lateral temporal lobe contralateral to the ear of stimulation.
Electroencephalography and Clinical NeurophysiologyLesions of frontal cortex diminish the auditory mismatch negativity
330 Citations1994Kimmo Alho, David L. Woods +3 more
The results suggest that DPFCx andDPFCx-temporal projections play a critical role in involuntary orienting to physical changes in sequences of non-attended auditory stimuli.
Journal of Cognitive NeuroscienceCentral Auditory System Plasticity Associated with Speech Discrimination Training
323 Citations1995Nina Kraus, Therese McGee +4 more
The results demonstrate that listening training can change the neurophysiologic responses of the central auditory system to just-perceptible differences in speech.
Annals of NeurologyImpaired auditory frequency discrimination in dyslexia detected with mismatch evoked potentials
319 Citations1999Torsten Baldeweg, A.J. Richardson +3 more
It is possible that in dyslexia a persistent sensory deficit in monitoring the frequency of incoming sound may impair the feedback control necessary for the normal development of phonological skills.
NeuroreportTemporal window of integration revealed by MMN to sound omission
317 Citations1997Hirooki Yabe, Mari Tervaniemi +2 more
The mismatch negativity (MMN) component of the event-related potentials (ERP) reflects the automatic detection of sound change and was elicited by a stimulus omission in a sequence of regularly spaced tone pips only when the SOA was shorter than 150 milliseconds.
NeuroreportAttentional orienting and reorienting is indicated by human event-related brain potentials
316 Citations1998Erich Schröger, Christian M. Wolff
The ‘reorienting negativity’ (RON) probably reflects processes in the context of reorienting towards task-relevant aspects of stimulation following distraction following distraction.
Archives of General PsychiatryImpaired Mismatch Negativity Generation Reflects Widespread Dysfunction of Working Memory in Schizophrenia
311 Citations1995Daniel C. Javitt
The present study demonstrates that the neurophysiological deficits associated with schizophrenia, as reflected in cognitive event-related potential generation, are pervasive, extending even to the level of the sensory cortex.
NeuroreportThe time course of auditory perceptual learning
301 Citations1998Kelly L. Tremblay, Nina Kraus +1 more
It is reported that training-associated changes in neural activity can precede behavioral learning, suggesting that speech-sound learning occurs at a pre-attentive level which can be measured neurophysiologically (in the absence of a behavioral response) to assess the efficacy of training.
PubMedEvoked potential audiometry.
282 Citations1976Picton Tw, David L. Woods +2 more
As well as providing an accurate means of determining the extent of a hearing loss, evoked potential studies can also provide information concerning the type and location of such a defect.
Audiology and NeurotologyMismatch Negativity-The Measure for Central Sound Representation Accuracy
276 Citations1997Risto Näätänen, Kimmo Alho
The mismatch negativity (MMN), elicited by any discriminable change in a repetitive sound even when this sound is not attended to, provides a pre-perceptual physiological measure of the accuracy of the central sound representation in the human brain.
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265 Citations1999C. Fischer, Dominique Morlet +4 more
It is demonstrated that the recording of MMN and the auditory N100 can be a very useful aid in the assessment of coma and in predicting whether or not a patient will regain consciousness.
Electroencephalography and Clinical NeurophysiologyEvoked potential correlates of stimulus deviance during wakefulness and sleep in cat — animal model of mismatch negativity
264 Citations1987Valéria Csépe, G. Karmos +1 more
Auditory evoked potentials elicited by standard (STs) and deviant tones (DTs) of different probabilities were studied in freely moving cats during wakefulness and sleep and a large double peaked negativity, so-called mismatch negativity, was evoked by the unattended low probability DTs.
NeuroreportRepresentation of abstract attributes of auditory stimuli in the human brain
263 Citations1992Jukka Saarinen, Petri Paavilainen +3 more
Representations of abstract attributes of auditory stimuli in the human brain were demonstrated using the mismatch negativity (MMN), an event-related potential component elicited by a change in a repetitive sound.
PsychophysiologyShort‐Term Habituation and Dishabituation of the Mismatch Negativity of the ERP
261 Citations1984Mikko Sams, Kimmo Alho +1 more
It was found that the mismatch negativity evoked in both conditions by the first deviant was considerably larger than to the second deviant, and the first standard following the first Deviant evoked the mismatchitivity.
Biological PsychologySequential effects on the ERP in discriminating two stimuli
256 Citations1983Mikko Sams
It was found that when a few consecutive repetitions of one stimulus occurred, the ERPs to the other stimulus immediately after those repetitions included features resembling those of the ERP to the infrequent stimulus usually observed in the so called 'oddball paradigm'.
Biological PsychologyThe duration of a neuronal trace of an auditory stimulus as indicated by event-related potentials
249 Citations1987S Mäntysalo, Risto Näätänen
The present study aimed at determining the duration of the assumed neuronal representation by varying the inter-stimulus interval (ISI) of a stimulus block, and found that a clear MMN was elicited by the deviant stimulus when the ISI was 1 or 2 s, but not whenThe ISI was 4 or 8 s.
Electroencephalography and Clinical Neurophysiology/Evoked Potentials SectionImpaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval
245 Citations1998D.C. Javitt, Sandra Grochowski +2 more
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The Journal of the Acoustical Society of AmericaEffect of Changes in Stimulus Frequency and Intensity on Habituation of the Human Vertex Potential
245 Citations1968Robert A. Butler
The notion that changes in stimulus frequency and increases in stimulus intensity activate new neural units was adopted to explain the data and it was asserted that habituation of the V potential is greatest when the same neural units are repeatedly activated and least when new Neural Unit brought into play.
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Experimental Aging ResearchAging Effects on Auditory Processing: An Event-Related Potential Study
133 Citations1996Eero Pekkonen, Teemu Rinne +4 more
This finding indicates that automatic stimulus discrimination per se is not impaired with normal aging, however, with a 4.5-s ISI the MMN/N2b-complex attenuated significantly more in the older than younger subjects, suggesting that the stimulus trace decays faster or that involuntary attention switching is less sensitive with aging.
NeuroreportAuditory sensory memory impairment in Alzheimerʼs disease
133 Citations1994Eero Pekkonen, Veikko Jousmäki +3 more
The recorded ERP components suggest that the memory trace decays faster in the AD patients than in age-matched healthy controls, and this suggests that the neural basis of sensory memory in audition is impaired in AD.
PsychophysiologyProcessing of auditory deviants with changes in one versus two stimulus dimensions
132 Citations1995Erich Schröger
In the attend condition, the deviance-related ERP effects were not additive in the N2b and P3 range, implicating that the neural processes involved in the conscious detection of changes in location and frequency were not independent.
Clinical NeurophysiologyStability of the mismatch negativity under different stimulus and attention conditions
116 Citations1999Norbert Kathmann, Thomas Frodl +1 more
The study shows that the deviant type as well as the attentional condition may have substantial effects on the stability and replicability of MMN potentials.
Journal of Cognitive NeuroscienceThe Role of Large-Scale Memory Organization in the Mismatch Negativity Event-Related Brain Potential
111 Citations2001István Winkler, Erich Schröger +1 more
Because the MMN indexes preattentive auditory processing, the present results provide evidence that large-scale preperceptual organization of auditory events occurs despite attention being directed away from the auditory stimuli.
Cognitive Brain ResearchAnatomical substrates of auditory selective attention: behavioral and electrophysiological effects of posterior association cortex lesions
108 Citations1993David L. Woods, Robert T. Knight +1 more
Event-related brain potentials (ERPs) and reaction times) were recorded in an auditory selective attention task in control subjects and two groups of patients with lesions centered in the temporal/parietal junction, and different roles of T/P and IPL cortex are supported.
Electroencephalography and Clinical NeurophysiologyMismatch negativity area and age-related auditory memory
108 Citations1993Eero Pekkonen, Veikko Jousmäki +2 more
Using the difference area between the deviant and standard ERP to evaluate the age and interstimulus interval (ISI) dependence of MMN, MMN area was quite stable regardless of age with 1 sec ISI and with 3 sec ISI, and was significantly smaller in the old than in the young subjects.
NeuroreportPredictability of stimulus deviance and the mismatch negativity
107 Citations1998Elyse Sussman, Walter Ritter +1 more
Results demonstrate that, unlike the P3 component, the MMN is sensitive to the predictable occurrence of stimulus deviance when the predictability can be detected by the brain within the estimated limits of sensory memory.
Electroencephalography and Clinical Neurophysiology/Evoked Potentials SectionIs it really a mismatch negativity? An assessment of methods for determining response validity in individual subjects
104 Citations1997Therese McGee, Nina Kraus +1 more
Criteria based on measurements of response area, onset latency, and duration were the best indicators of response validity and statistical methods which utilized response subaverages were the poorest indicators ofresponse validity.
Journal of Cognitive NeuroscienceInteractions between Transient and Long-Term Auditory Memory as Reflected by the Mismatch Negativity
104 Citations1996István Winkler, Nelson Cowan +3 more
The present results suggest that the transient auditory sensory memory representation underlying the MMN is facilitated by a longer-term representation of the corresponding stimulus.
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