Social environment and brain biogenic amine metabolism in rats.
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TL;DR
Brain serotonin metabolism showed minimal changes in differentially housed rats and reserpine and para-chlorophenylalanine treatment affected brain norepinephrine levels more after isolation than after grouped housing.
Abstract
Abstract : The effects of living alone or in groups of three for four weeks on brain biogenic amine metabolism was investigated in rats. Isolation produced an increase in brain norepinephrine turnover relative to the grouped subjects. In addition, reserpine and para-chlorophenylalanine treatment affected brain norepinephrine levels more after isolation than after grouped housing. Brain serotonin metabolism showed minimal changes in differentially housed rats. These findings are in direct contrast to results from studies on psychosocial determinants of brain amine metabolism in mice. (Author)