Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico
Emerging infectious diseasesPublished 1 December 2004Open access
David W. C. Beasley, C. Todd Davis, José G. Estrada-Franco, Roberto Navarro‐López, Arturo Campomanes-Cortes, Robert B. Tesh
Citations85
SJR quartileQ1
SJR score1.88
SNIP1.47
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TL;DR
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide and 4 amino acid differences from the NY99 prototype, suggesting the emergence of an attenuating mutation.
Abstract
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
Keywords
Medicine
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