Decreased Fentanyl and Alfentanil Dose Requirements with Age. A Simultaneous Pharmacokinetic and Pharmacodynamic Evaluation
Survey of AnesthesiologyPublished 1 October 1987
James C. Scott, D. R. Stanski
Citations423
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TL;DR
The decreased dose requirement in the elderly had a pharmacodynamic explanation, using the EEG as a measure of narcotic drug effect.
Abstract
Stanford University School of Medicine and Palo Alto Veterans Administration Medical Center, Stanford and Palo Alto, California
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics