Role of Endotoxin and Interleukin-1 in Modulating ACTH, LH and Sex Steroid Secretion
Advances in experimental medicine and biologyPublished 1 January 1990
Catherine Rivier
Citations52
SJR quartileQ3
SJR score0.37
SNIP0.20
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TL;DR
Results suggest that at least part of the ability of LPS to alter endocrine functions appears to depend upon endogenous interleukin-1.
Abstract
We have shown that the endotoxin LPS acted both at the level of the brain and the gonads to stimulate the hypothalamic-pituitary-adrenal, and inhibit the hypothalamic-pituitary-gonadal, axis. Exogenously administered IL-1 mimics most of the effects of LPS on pituitary activity. In addition, antibodies against IL-1 receptors can interfere with LPS-induced ACTH secretion. These results suggest that at least part of the ability of LPS to alter endocrine functions appears to depend upon endogenous interleukin-1.
Keywords
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