Top Research Papers on Breast Cancer

A range of treatment options reflects the complexity of breast cancer therapy today, with standard therapy options including targeted approaches such as CDK4 and CDK6 inhibitors, PI3K inhibitors, PARP inhibitors, and anti-PD-L1 immunotherapy, depending on tumour type and molecular profile.

The importance of breast adipose tissue in breast development and its involvement in breast changes happening during pregnancy, lactation and involution is discussed, with an overview on its involved in the various steps of breast cancer development and progression.

The article presents up-to-date information for doctors of various specialties: oncologists, surgeons, mammologists, obstetricians and gynecologists, general practitioners on the problems of modern treatment of breast cancer.

The USPSTF concludes that the current evidence is insufficient to determine the balance of benefits and harms of screening mammography in women 75 years or older and the balance of benefits and harms of supplemental screening for breast cancer with breast ultrasound or magnetic resonance imaging (MRI), regardless of breast density.

Postmenopausal women should also be offered postoperative bisphosphonates, and patients at high risk of breast cancer may be candidates for risk-reducing medications.

The application of nanomedicine including CRISPR nanoparticle, exosomes for the treatment of BC/TNBC and other molecular targets available such as poly (ADP-ribose) polymerase (PARP), epidermal growth factor receptor (EGFR), Vascular endothelial growth factor (VEGF), etc. for further exploration have been discussed.

This cohort study investigates the clinicopathological characteristics and breast cancer–specific survival of patients with single hormone receptor–positive breast cancer.

Progress against breast cancer mortality could be accelerated by mitigating racial disparities through increased access to high‐quality screening and treatment via nationwide Medicaid expansion and partnerships between community stakeholders, advocacy organizations, and health systems.

Progress against breast cancer could be accelerated by mitigating racial, ethnic, and social disparities through improved clinical trial representation and access to high-quality screening and treatment.

The results suggest that estrogen deprivation failes to be active in case of PIK3CA-mutation, and the impact of Pik3 CA-mutations on RFI and OS was heterogeneous.

An up to date overview of the biology, genetics, and histology of MBC with comparison to female breast cancers and differential diagnosis from histological mimics is provided.

It is proposed that viewing ferroPTosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.

Socioeconomic factors, cancer stage, tumor characteristics (size and grade), and high Charlson-Dayo score contributed to higher mortality among male patients diagnosed with breast cancer.

A review of autophagy focusing on its interplay with targeted drugs used for breast cancer treatment and its potential to enhance tumor cell death by diverse anti-cancer therapies is presented.

Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breast cancer have enhanced the comprehension and precision treatment of this disease. The mechanisms of tumorigenesis and progression of breast cancer have been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, and circadian rhythms. Technological advancements, particularly those integrated with artif...

The Lancet Breast Cancer Commission report shows inequities in prevention, detection, treatment, and supportive care, with many groups of people with breast cancer being systematically left behind and forgotten. This is a global error as people with breast cancer are indispensable to our culture and socioeconomic system.\nNew findings: The number of people living with metastatic breast cancer is unknown and many do not receive appropriate care. With adequate resources and a shift in attitudes, it might be possible to cure some people, treat most, alleviate the suffering of all, and abandon no ...

Importance: Young women with breast cancer are increasingly choosing bilateral mastectomy (BM), yet little is known about short-term and long-term physical and psychosocial well-being following surgery in this population. Objective: To evaluate the differential associations of surgery with quality of life (QOL) and psychosocial outcomes from 1 to 5 years following diagnosis. Design, Setting, and Participants: Cohort study. Setting: Multicenter, including academic and community hospitals in North America. Participants: Women age ≤40 when diagnosed with Stage 0-3 with unilateral breast cancer be...

Omission of radiotherapy was associated with an increased incidence of local recurrence but had no detrimental effect on distant recurrence as the first event or overall survival among women 65 years of age or older with low-risk, hormone receptor-positive early breast cancer.

The intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation is discussed in order to appreciate the molecular pathways that have been described to drive adipocyte dedifferentiation.

A review of studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer hopes that summarizing CAF‐related studies from a historical perspective will help to accelerate the development ofCAF‐targeted therapeutic strategies for breast cancer.