Top Research Papers on Hypertension
Dive into the most influential research papers on Hypertension and gain valuable insights on managing and understanding high blood pressure. This collection highlights pivotal studies that shed light on effective treatments and the latest advancements in this critical area of health.
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Ambulatory Blood Pressure Monitoring to Diagnose and Manage Hypertension
137 Citations 2021Qi‐Fang Huang, Wen‐Yi Yang, Kei Asayama + 5 more
Hypertension
Evidence is still waiting for evidence from randomized clinical trials to prove that out-of-office BP monitoring is superior to office BP in adjusting antihypertensive drug treatment and in the prevention of cardiovascular complications.
Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension
689 Citations 2021Weili Zhang, Shuyuan Zhang, Yue Deng + 25 more
New England Journal of Medicine
In older patients with hypertension, intensive treatment with a systolic blood-pressure target of 110 to less than 130 mm Hg resulted in a lower incidence of cardiovascular events than standard treatment withA target of 130 to less less than 150mm Hg.
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension
236 Citations 2020Xuefang Yan, Jiajia Jin, Xinhuan Su + 9 more
Circulation Research
HSIH could be transferred by fecal microbiota transplantation, indicating the pivotal roles of intestinal flora in hSIH development, and a novel mechanism different from inflammation/immunity by which intestinal flora regulated BP is revealed.
Effect of salt substitution on community-wide blood pressure and hypertension incidence
193 Citations 2020Antonio Bernabé‐Ortiz, Víctor G. Sal y Rosas, Vilarmina Ponce-Lucero + 7 more
Nature Medicine
A step-wedged cluster randomized trial demonstrates population-wide reductions in blood pressure, which appear to be higher in individuals with hypertension, as well as reductions in risk of hypertension by around 50% for those without hypertension at baseline, after community-wide replacement of regular salt with a potassium-enriched alternative.
Blood Pressure Response to Oral Calcium in Persons with Mild to Moderate Hypertension
199 Citations 2020David A. McCarron, Cynthia D. Morris
Annals of Internal Medicine
The blood pressure response of 48 hypertensive persons and 32 normotensive persons to elemental calcium (as the carbonate or citrate salt), 1000 mg/d for 8 weeks, was assessed in a random fashion.
Nonpharmacologic Interventions for Reducing Blood Pressure in Adults With Prehypertension to Established Hypertension
165 Citations 2020Jinming Fu, Yupeng Liu, Lei Zhang + 13 more
Journal of the American Heart Association
For adults with prehypertension to established hypertension, high‐quality evidence indicated that the Dietary Approach to Stop Hypertension (DASH) was superior to usual care and all other nonpharmacologic interventions in lowering systolic BP.
Cuffless blood pressure measuring devices: review and statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability
172 Citations 2022George S. Stergiou, Ramakrishna Mukkamala, Alberto Avolio + 21 more
Journal of Hypertension
Cuffless BP devices have considerable potential for changing the diagnosis and management of hypertension, however, fundamental questions regarding their accuracy, performance, and implementation need to be carefully addressed before they can be recommended for clinical use.
Effect of Exercise Training on Ambulatory Blood Pressure Among Patients With Resistant Hypertension
116 Citations 2021Susana Lopes, José Mesquita Bastos, Catarina Garcia + 12 more
JAMA Cardiology
A 12-week aerobic exercise program reduced 24-hour and daytime ambulatory BP as well as office systolic BP in patients with resistant hypertension, providing clinicians with evidence to embrace moderate-intensity aerobic exercise as a standard coadjutant therapy targeting this patient population.
Trends in Blood Pressure and Hypertension Among US Children and Adolescents, 1999-2018
129 Citations 2021Shakia T. Hardy, Swati Sakhuja, Byron C. Jaeger + 4 more
JAMA Network Open
It is suggested that from 1999-2002 to 2015-2018, mean systolic blood pressure decreased among adolescents aged 13 to 17 years and mean DBP decreased among children and adolescents aged 8 to 12 and 13 to 13 years, respectively, in the US.
Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes in Patients With Hypertension
142 Citations 2021Nayyra Fatani, Dave L. Dixon, Benjamín W. Van Tassell + 2 more
Journal of the American College of Cardiology
Time in systolic blood pressure target range independently predicts major adverse cardiovascular event risk, and participants with greater time in target range were younger, had lower 10-year cardiovascular risk and lower baseline systolics blood pressure.
Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension
1369 Citations 2021Bin Zhou, Pablo Perel, George A. Mensah + 1 more
Nature Reviews Cardiology
Population-level measures, such as increasing the availability and affordability of fresh fruits and vegetables and lowering the sodium content of packaged and prepared foods, can lower blood pressure in the entire population.
Racial and Ethnic Disparities in Hypertension: Barriers and Opportunities to Improve Blood Pressure Control
159 Citations 2023Aleksandra A. Abrahamowicz, Joseph E. Ebinger, Seamus P. Whelton + 2 more
Current Cardiology Reports
The barriers and opportunities associated with racial and ethnic disparities in blood pressure (BP) control are characterized along with the unique genetic, social, economic, and cultural diversity within these groups that contribute to ongoing BP management inequalities.
Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement
107 Citations 2022Hirohito Metoki, Noriyuki Iwama, Hirotaka Hamada + 4 more
Hypertension Research
This narrative review focused on recent reports on hypertensive disorders of pregnancy, including those related to blood pressure measurement and classification, as well as guidelines for the use of antihypertensive drugs.
Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension
126 Citations 2022Aletta E. Schutte, Tazeen H. Jafar, Neil R Poulter + 36 more
Cardiovascular Research
It is reported that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths.
Global and national high blood pressure burden and control
139 Citations 2021Tu Ngoc Nguyen, Clara K Chow
The Lancet
High blood pressure is a leading modifiable cause of premature death and one of WHO's global targets for the prevention of non-communicable diseases. Monitoring high blood pressure globally while understanding what is happening at a country level is important to identify tangible and customised solutions for local, national, and global polices to address high blood pressure. As reported in The Lancet by the NCD Risk Factor Collaboration (NCD-RisC), 1 NCD Risk Factor Collaboration (NCD-RisC)Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a po...
Effect of Home Blood Pressure Monitoring via a Smartphone Hypertension Coaching Application or Tracking Application on Adults With Uncontrolled Hypertension
167 Citations 2020Stephen D. Persell, Yaw Peprah, Dawid Lipiszko + 5 more
JAMA Network Open
In this randomized clinical trial of 297 adults with uncontrolled hypertension, participants randomized to a smartphone coaching app did not have lower blood pressure at 6 months compared with those receiving a blood pressure tracking app.
Trends in Blood Pressure Control Among US Adults With Hypertension, 1999-2000 to 2017-2018
880 Citations 2020Paul Muntner, Shakia T. Hardy, Lawrence J. Fine + 4 more
JAMA
Whether BP control among US adults with hypertension changed from 1999-2000 through 2017-2018 was determined to be a cross-sectional analysis of National Health and Nutrition Examination Survey data, weighted to be representative of US adults.
A review of machine learning in hypertension detection and blood pressure estimation based on clinical and physiological data
124 Citations 2021Erick Axel Martinez-Ríos, Luis Montesinos, Mariel Alfaro-Ponce + 1 more
Biomedical Signal Processing and Control
The use of machine learning techniques in medicine has increased in recent years due to a rise in publicly available datasets. These techniques have been applied in high blood pressure studies following two approaches: hypertension stage classification based on clinical data and blood pressure estimation based on related physiological signals. This paper presents a literature review on such studies. We aimed to identify the best practices, challenges, and opportunities in developing machine learning models to detect hypertension or estimate blood pressure using clinical data and physiological ...
2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement
735 Citations 2021George S. Stergiou, Paolo Palatini, Gianfranco Parati + 6 more
Journal of Hypertension
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Seasonal variation in blood pressure: Evidence, consensus and recommendations for clinical practice. Consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability
104 Citations 2020George S. Stergiou, Paolo Palatini, Pietro Amedeo Modesti + 17 more
Journal of Hypertension
This Consensus Statement by the European Society of Hypertension Working Group on BP Monitoring and Cardiovascular Variability provides a review of the evidence on the seasonal BP variation regarding its epidemiology, pathophysiology, relevance, magnitude, and the findings using different measurement methods.