Top Research Papers on OCD

The novel concept of “autoimmune OCD” is proposed for a small subgroup of OCD patients, and clinical signs based on the PANDAS/PANS criteria and from recent experience with autoimmune encephalitis and autoimmune psychosis are suggested.

The authors have compiled the available evidence to make a clear statement on whether DBS for OCD is established therapy.

A systematic review of schema therapy for anxiety disorders, OCD, and PTSD showed that schema therapy can lead to beneficial effects in disorder‐specific symptoms and early maladaptive schemas and uncovered substantial methodological limitations in most studies.

To estimate the worldwide prevalence of obsessive-compulsive disorder, examine whether women are at greater risk than men, and explore other potential moderators of OCD prevalence to explain variability in community-based epidemiologic studies.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Structural brain imaging data from ENIGMA consortium data suggests robust but subtle differences across different age groups among ADHD, ASD, and OCD, which support previous work emphasizing structural brain differences in these disorders.

The results of the study show that the effect of COVID-19 fear on OCD is mediated by emotional reactivity, experiential avoidance and depression-anxiety.

Connections between ASD and SUD and the impact on development, screening and treatment are explored and culturally constructed narratives associated with both diagnoses are proposed to be responsible for the dearth of research and literature.

The findings suggest that women with MDD and anxiety disorders have elevated rates of EDs, and it is therefore imperative to screen for disordered eating in these populations.

The results support the need to improve relapse prevention during the period of social restrictions and develop alternative strategies such as online consultations and digital psychiatric management.

Results showed that patients with OCD had higher scores on all OC symptom dimensions and symptom severity during the pandemic as compared to their scores from before the Pandemic, and regression analyses indicated that COVID-19-related stress responses significantly predicted the observed increase in specific OC symptoms and general severity.

Underlying mechanisms of observed pleiotropy are examined, including genetic effects on neurodevelopment, diverse actions of regulatory elements, mediated effects, and spurious associations of genomic variation with multiple phenotypes.

Bipolar disorder has a yearly prevalence of 2%. Other mental and physical conditions occur with bipolar disorder, which is also associated with an increased risk of suicide. Treatment is complex and relies on lithium or intermittent use of antipsychotic drugs.

The title of this Primer (Histiocytic disorders) was chosen to differentiate the above diseases from Langerhans cell sarcoma and malignant histiocytosis, which are hyperproliferative lesions typical of cancer.

The diagnostic assessment of vestibular syndromes is much easier for clinicians now that it has been internationally standardized, but there is still a lack of randomized, controlled trials on the treatment of, for example, Menière's disease, Vestibular migraine, and "cerebellar vertigo."

Evidence is reviewed on the epidemiology, mechanisms, screening, and treatment of bipolar disorders, which shows targeting medical and psychiatric comorbidity, integrating adjunctive psychosocial treatments, and involving caregivers have been shown to improve health outcomes for people with bipolar disorders.

Reducing the large burden of disease from anxiety disorders in individuals and worldwide can be best achieved by timely, accurate disease detection and adequate treatment administration, scaling up of treatments when needed.

It has been further demonstrated that reducing the duration of untreated illness within three years of onset is associated with a better outcome and this has led to the rollout of FREED, an early intervention service in the UK.

Cognitive behavioral therapy is the psychotherapy with the most evidence of efficacy for anxiety disorders compared with psychological or pill placebo and first-line treatments for Anxiety disorders include cognitive behavioral therapy, SSRIs such as sertraline, and SNRIssuch as venlafaxine extended release.

The role of NO and SNO in the progression of neurodevelopmental, psychiatric and neurodegenerative disorders, with special attention to autism spectrum disorder (ASD), is summarized and mechanistic insights into the contribution of NO in diverse brain disorders are provided.