Top Research Papers on Ulcerative Colitis

The fully-automated UC-SCALE algorithm provides a topological representation of the score as a marker of disease severity that correlates highly with clinical metrics and holds promise to enhance disease severity evaluation in both clinical trials and everyday practice.

massive accumulation of oligoclonal CD4+ T cells of athymic origin with the phenotype of Th1 memory/effector T cells in the colonic lamina propria of a histocompatible, immunodeficient host elicits a pancolitis that morphologically mimics human UC.

In UC but not in CC and non‐IBD controls, the increased number of IgG‐producing cells are largely committed to produce IgG against hTM5‐related epitope(s), a putative autoantigen in UC.

Colonocytes of UC patients show premature shortening of telomeres, which might explain the increased and earlier risk of cancer in this disease.

In this review, important elements of UC pathology are thought to be the intestinal bacteria, gut mucus, and the mucosa-associated immune system.

A five year follow-up of primary sclerosing cholangitis (PSC) in a 29-year-old man with ankylosing spondylitis (AS) and ulcerative colitis (UC) is reported, the first case report of such coexistence.

It is suggested that an accelerated step-up approach may reduce colectomy rates in paediatric UC patients and is correlated to ESR and PUCAI at 1 year, steroid treatment dropped from 82% to 24% and steroid-free remission rate 76%.

One or two cases treated by coli vaccine seemed to give encouraging results, and this supported the relation between the coli group of organisms and ulcerative colitis, but it is only fair to add that in other instances coli vaccine failed.

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Ulcerative colitis is a form of inflammatory bowel disease. It is a chronic relapsing condition affecting the colon and rectum and can cause a variety of symptoms, the commonest of which is bloody diarrhoea. Prompt diagnosis, as well as flare identification and management by primary care clinicians can improve patient outcomes such as disease progression and effects on quality of life.

In the UK, nurses’ perception of UC was more aligned with physicians’ rather than pts’ perceptions, suggesting both nurses and physicians may underestimate the burden of UC perceived by pts.

The patient has kept well for the past nine imionths and appears to be a case in which colotomy was done when the patient was almost extremis and in which the colotoilny wound was closed after five years.

Mr Makins's experience of relapse following operation to close a colotomy wound had occurred in a case of Dr. Phillips's, the relapse being fatal, and he thought the advisability of operation must be decided on the merits of each individual case.

It is proposed to review recent research into the aetiology of ulcerative colitis, to describe its clinical features, differential diagnosis, prognosis, local and systemic complications and to omit the management of the condition.

In patients who recovered, crisis and improvement were preceded by an increase of lymphocytes and eosinophils, and spirochaetes persisted in the fatal cases.

This chapter discusses the presentation and management of ulcerative colitis with a special emphasis on management of acute severe colitis.

Surgery has been at once the cause of many disasters and the means of saving many lives; it is of the greatest value when applied at the appropriate time; it should be availed of when the occasion requires it.

An overview of the criteria for evaluating screening and surveillance programs and applies the criteria to the available evidence to determine the effectiveness of the surveillance of patients with ulcerative colitis is provided.

The muscle hypertrophy and the perforation would conform with Wilson's theory of appendiceal diverticula,l which in the absence of a constriction must represent the continuous efforts of the appendix to expel its unusually profuse and viscous secretions.

The subcommittee has the best possible reasons for making these apparently invidious distinctions, but the logic of insisting upon much lower limits for many foods cunsumed in infinitely smaller amounts is impossible to follow.