Top Research Papers on Ulcerative Colitis

Skin and soft tissue infections (SSTIs) are among the most common sites of bacterial infection and a cause of considerable morbidity and risk factors include the presence of neoplasia in the original operative specimen,Type C changes and diagnosis of UC of more than 10 years.

A chronology of key events leading to and following the formation of the Asociaţia Persoanelor cu Boli Inflamatorii Intestinale din România, which led to the establishment of the Romanian Association of People with IBD.

During follow-up of patients in the PPT, Laiyemo et al found that, although many low-risk patients have been verutilizing surveillance colonoscopy, underutilization as common among high- risk patients (Gastroenterolgy 2008;134:A111).

The hyperemia component of the EUS-UC score performed significantly better than the original index from which it was derived, but the reliability of the DOI component was suboptimal.

Bowel wall thickness (BWT) and UC-IUS Index performed in children at diagnosis in comparison to endoscopy using the Mayo score and correlated highly positively with the Mayo subscore in children with UC.

It is shown that appendicectomy has a strong negative association with UC and a more benign UC phenotype and PSC, and removal of an appendix in patients who are susceptible to UC may predispose to a more innocuous UC phenotype.

In Pediatric patients with newly diagnosed UC, TABUS was a useful tool, with the UC-IUS and BWT correlating well with their endoscopic, clinical, and biochemical disease activity.

According to many studies issued in the literature, a greater fraction of thyroid disease in inflammatory bowel disease patients has been noted.

A randomized controlled trial of a humanized Alpha 4 Beta 7 antibody in Ulcerative Colitis and its application in UC is described.

Overall there are strong indicators of metabolic changes in the urine of patients with active UC and control samples and some of the putative markers e.g. glutamine are relatively abundant and may be suitable for a simple urinary test.

UC is inadequately managed in primary care once remission is induced, with several patients missed routine surveillance colonoscopy and blood tests.

The cytokine gene polymorphisms evaluated in this study do not seem to be strong risk factors for the overall disease susceptibility in UC, but may be involved in determining the severity of the disease.

Investigating the human TM (hTM) isoforms recognized by serum IgG from UC and whether hTM IgG antibodies are present in healthy UC relatives concluded that autoimmunity to hTM1 and hTM5 is a feature of UC, while h TM1 IgG differentiate UC relatives from controls.

Qingweilichang Capsule can improve the pathological changes and regulate the immunology functions of rats with UC and reduce inflammatory reactions including the tissue ulceration, cell infiltration and the tissue edema.

This research highlights the need to select patients with a history of Crohn’s Disease or ulcerative colitis to be screened for this condition before they begin treatment with chemotherapy.

The frequency and duration of bowel rest orders and the number of meals missed because of these orders were assessed and predictors of unjustified fasting in admitted UC patients were identified.

There is a high burden of unjustified underfeeding among hospitalized patients with UC, particularly in patients admitted without evidence of objective disease flare, which may lead to nutritional compromise in an at-risk population, and targeted quality improvement interventions are needed.

The SCCAI is a simple tool that can be accurately self administered, correlates well with a more complicated disease activity index, & can be used to define relapse of UC with high specificity & sensitivity.

The TUMMY-UC, constructed from PRO and ObsRO versions, is a reliable, valid and responsive index, which can be now used in practice and clinical trials.

The case of a patient with ulcerative colitis who achieved remission with infliximab, however, after about two years of infusions, developed evidence of non-specific interstitial pneumonitis (NSIP); clinical, laboratory, and radiographic findings were sufficient in establishing this diagnosis.

A study of HLA class II gene association with UC in a large group of white Madrid patients and ethnically matched controls, using molecular biology techniques to investigate whether any allelic subspecificity within the HLA‐DR2 group is associated with susceptibility to or protection against UC.

The UC Horizons Project raised a series of eminently practical questions about the management of UC and provided responses based on the best scientific evidence available, although the quality of the evidence was markedly heterogeneous.

In the experience FT might be safe but activates a temporary systemic immune response and the general well-being improved from poor to very well at week 12 in the other 3 patients, but the median total Mayo score improved only from 11 to 9.

UC HAT did not improve disease activity, QoL, or adherence compared to BAC after 1 year, and research is indicated to determine if telemedicine improves outcomes in patients with IBD.

HIF-1α as a transcriptional factors may be involved in the pathogenesis and activity of UC.

A high prevalence of infection with at least one or six non-pathogenic and pathogenic intestinal protozoa in UC patients in the Isfahan region is revealed.

A model developed, based on simplified decision tree pathways, can be used for economic evaluations of interventions to reduce the risk of flare in UC and to help understand the costly aspects of managing ulcerative colitis.

This research highlights the need to select patients with a history of Crohn’s Disease or ulcerative colitis to be screened for this condition before they begin treatment with chemotherapy.

Data support conceptual equivalence between the PRO and obsRO TUMMY-UC versions, and provide support for their incorporation into one score.

Detailed analysis of QOL's "retrospective" findings is not available.

The data seem to indicate that an activation of Th2 immune response is involved in the pathogenesis of UC, but not of CD, and this finding indicates that serum soluble CD30 measurement may be helpful for differentiating these two forms of inflammatory bowel disease.

This review emphasizes the virological tools that are recommended for exploring CMV colitis during inflammatory bowel diseases (IBD) and underlines the interest of using ganciclovir for treating flare-ups associated to CMVcolitis in UC patients.

Anti-OMPC may be a useful marker not only for diagnosis of UC but also in determination of the disease activity among UC patients.

CYK group could reduce colon tissue P-pg level, reduce resistance, improve the therapeutic effect of drugs, and clarify the treatment of ulcerative colitis and possible mechanism of action.

A qualitative study on YouTube to determine if the patient journey from a subjective perspective is truly linear for those who suffer from ulcerative colitis discovers that the reality of the patient journey is, in fact, non-linear.

The DAI and histological scores of mice treated with probiotics were much better than those did not treat, and the effect of mucosa protection was better in L.acidophilus treated mice.

HIGH INCIDENCE of HEPATIC DISEASE (HD) ASSOCIATED with ULCERATIVE COLITIS(UC) in children in UC in children with special needs and adults is found to be significant.

This case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM is a rare case in that the respiratory disorder is apparently related to UC.

Interventional inflammatory bowel disease (IIBD) is going to play a major role in complex IBD including ulcerative-colitis associated neoplasia (UCAN) and postoperative complications after ileal pouch-anal anastomosis (IPAA) in ulcerative colitis (UC). We performed a literature search in PubMed using keywords such as “UCAN” and “endoscopic management of pouch complications,” After screening 1221 citations, finally, 91 relevant citations were identified for the systematic review. Endoscopic recognition of dysplasia should be done by high-definition white light endoscopy (HD-WLE) or dye-based/vi...

An UC-IUS index was developed which showed strong correlation with endoscopic disease activity using internal validation and is currently being validated in prospective studies.

Two miRNAs and three genes associated with the differential manifestations of UC in Uyghur and Han population were identified, which were potential biomarkers of UC.

Patients followed in small hospitals seem to know their disease better, are followed more frequently in the clinic, and have better access in case of a flare-up.

Patients followed in small hospitals seem to know their disease better, are followed more frequently in the clinic, and have better access in case of a flare-up.

It is suggested that more patients than gastroenterologists estimated chose to adapt their lives to accommodate UC rather than act to optimize therapy and adherence, and improved communication between patients and gastroenterologist, as well as better management strategies and education are necessary.

Study findings indicate that UC patients live with constant, unpredictable symptoms, where a flare-up becomes socially isolating along with anxieties of deteriorating health, and need relevant treatment provided quickly.

Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis and none assessing its relationship with lifestyle exposures.

It is confirmed that BrdU, Ki-67染色, and Brd U/Ki-67/BrdU-67 are in advanced stages of development.

A standardization method based on deep learning is introduced to address the issue of inconsistent diagnoses of ulcerative colitis by introducing a consensus model that considered only the images and labels on which more than half of the experts agreed.

Consumption below the current recommendation of total and insoluble dietary fiber is associated with clinical activity of UC, and those with clinically active UC consumed less total fiber and insoluble fiber.

The results do not support a relationship bctween ANCA and UC activity in this cohort of 180 patients.