Increased Amygdala and Decreased Dorsolateral Prefrontal BOLD Responses in Unipolar Depression: Related and Independent Features
Biological PsychiatryPublished 7 October 2006
Greg J. Siegle, Wesley K. Thompson, Cameron S. Carter, Stuart R. Steinhauer, Michael E. Thase
Citations855
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
Depressed individuals also display decreased relationships between amygdala and DLPFC activity, potentially signifying decreased functional relationships among these structures, though these may reflect separate mechanisms.
Abstract
Depression is associated with increased limbic activity in response to emotional information processing and decreased DLPFC activity in response to cognitive tasks though these may reflect separate mechanisms. Depressed individuals also display decreased relationships between amygdala and DLPFC activity, potentially signifying decreased functional relationships among these structures.
Keywords
PsychologyMedicineNeuroscience
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