Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis
American Journal of PsychiatryPublished 1 February 1997
Gene E. Alexander, Maura L. Furey, Cheryl Grady, Pietro Pietrini, Daniel R. Brady, Marc J. Mentis
Citations333
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
The results suggest that higher levels of premorbid ability are associated with greater pathophysiological effects of Alzheimer's disease among patients of similar dementia severity levels, and provide support for a cognitive reserve that can alter the clinical expression of dementia and influence the neurophysiological heterogeneity observed in Alzheimer's Disease.
Abstract
The results suggest that higher levels of premorbid ability are associated with greater pathophysiological effects of Alzheimer's disease among patients of similar dementia severity levels. These findings provide support for a cognitive reserve that can alter the clinical expression of dementia and influence the neurophysiological heterogeneity observed in Alzheimer's disease.
Keywords
Medicine
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