Computational perspectives on dopamine function in prefrontal cortex
Current Opinion in NeurobiologyPublished 1 April 2002
Jonathan D. Cohen, Todd S. Braver, Joshua W. Brown
Citations384
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SJR score2.54
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TL;DR
Dopamine and the prefrontal cortex are critical for thought and behaviour and computational models have tried to elucidate the specific and intricate roles of dopamine in the cortex at the neurophysiological, system and behavioral levels, with varying degrees of success.
Abstract
Dopamine and the prefrontal cortex are critical for thought and behaviour. Recently, computational models have tried to elucidate the specific and intricate roles of dopamine in the prefrontal cortex, at the neurophysiological, system and behavioral levels, with varying degrees of success.
Keywords
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Models of Working Memory: Mechanisms of Active Maintenance and Executive Control
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Evidence is provided that dopamine plays an important role in a specific cortical function in rhesus monkeys and that this role can be pharmacologically reversed with dopamine agonists.
Journal of NeuroscienceNeural Mechanisms of Visual Working Memory in Prefrontal Cortex of the Macaque
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Psychological ReviewContext, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia.
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The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHpx plays an important role in detoxifying increases in oxygen radicals.
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Journal of NeuroscienceA Neurocomputational Theory of the Dopaminergic Modulation of Working Memory Functions
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