MK-801 is cytotoxic to microglia in vitro and its cytotoxicity is attenuated by glutamate, other excitotoxic agents and atropine
Brain ResearchPublished 1 April 2001
Masaaki Hirayama, Masaru Kuriyama
Citations23
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
Cytotoxicity of MK-801 was reduced by the addition of atropine sulfate which suggested the presence of muscarinic receptor in microglia and the existence of glutamate receptor inmicroglia.
Abstract
We examined the cytotoxicity of MK-801 on cultured microglia and demonstrated its cytotoxicity. Cytotoxicity of MK-801 was reduced by the addition of L-glutamate, kainate and NMDA. The action of MK-801 was due to the direct action of microglia. It suggested the existence of glutamate receptor in microglia. Cytotoxicity of MK-801 was reduced by the addition of atropine sulfate which suggested the presence of muscarinic receptor in microglia.
Keywords
Neuroscience
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