Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate
Neuroscience LettersPublished 1 December 1991
Daniela Piani, Karl Frei, Kim Q., Michel Cuénod, A. Fontana
Citations416
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
Supernatants of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not, and might play a role in vivo in traumatic and cerebrovascular brain lesions.
Abstract
Supernatants (SN) of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not. This toxicity can be prevented by N-methyl-D-aspartate (NMDA) receptor antagonists. Macrophage SN contain high concentrations of glutamate. Reducing the glutamate level of macrophage SN, either by exposure to astrocytes or by enzymatic degradation abolished the toxic effect. Thus, macrophage neurotoxicity is mediated by glutamate acting on NMDA receptors, and might play a role in vivo in traumatic and cerebrovascular brain lesions.
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