Glutamate neurotoxicity and diseases of the nervous system
NeuronPublished 1 October 1988
Dennis W. Choi
Citations7,990
SJR quartileQ1
SJR score6.75
SNIP2.95
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Abstract
Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.
Keywords
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New England Journal of MedicineCalcium and Ischemic Injury
531 Citations1986Franklin H. Epstein, Joseph Y. Cheung +3 more
This study highlights the need to understand more fully the determinants of death and morbidity in patients diagnosed with central giant cell granuloma, which is a complication of multiple organ failure.
NatureAnatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites
525 Citations1983Daniel T. Monaghan, Vicky R. Holets +2 more
There are at least four distinct classes of 3H-L-glutamate binding sites which differ in their anatomical distribution, pharmacological profile and regulation by ions, and a third site may represent the KA receptor and a fourth binding site does not conform to present receptor classifications.
NeurologyProtective effects of NSAIDs on the development of Alzheimer disease
519 Citations2008Steven C. Vlad, Donald R. Miller +2 more
Long-term nonsteroidal anti-inflammatory drug (NSAID) use was protective against Alzheimer disease, and findings were clearest for ibuprofen.
Cellular Physiology and BiochemistryRole of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
508 Citations2007Silke Walter, Maryse Letièmbre +9 more
It is shown that a spontaneous loss-of-function mutation in the Tlr4 gene strongly inhibits microglial and monocytic activation by aggregated Alzheimer amyloid peptide resulting in a significantly lower release of the inflammatory products IL-6, TNFα and nitric oxide.
Trends in NeurosciencesNon-competitive antagonists of excitatory amino acid receptors
499 Citations1987John A. Kemp, Alan C. Foster +1 more
The ability of the non-competitive NMDA receptor antagonists to penetrate the brain following systemic administration, and the use-dependency of their antagonism may confer distinct therapeutic advantages in the treatment of neurological disorders where an overstimulation of NMDA receptors is thought to occur.
Journal of NeuroscienceRegulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
489 Citations2002Shin Nakagawa, Ji‐Eun Kim +7 more
The results suggest that the cAMP–CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis.
BrainRole of toll-like receptor signalling in A uptake and clearance
488 Citations2006Keishiro Tahara, Hong-Duck Kim +4 more
The results suggest that TLR signalling pathway(s) may be involved in clearance of Abeta-deposits in the brain and that TLRs can be a therapeutic target for Alzheimer's disease.
Trends in NeurosciencesElectrophysiological studies of NMDA receptors
482 Citations1987Philippe Ascher, Linda M. Nowak
G glycine potentiates the response to NMDA and some of the minor states resemble the major conductance states opened by non-NMDA agonists.
Seminars in OncologyCancer Prevention With Natural Compounds
476 Citations2010Norleena Gullett, A.R.M. Ruhul Amin +7 more
Potential natural cancer preventive compounds and their mechanisms of action are discussed.
Critical Reviews in BiochemistryMechanism of Transport and Storage of Neurotransmitter
474 Citations1987Baruch I. Kanner, Shimon Schuldiner
This review will focus on the bioenergetics, mechanism, and molecular basis of neurotransmitter transport, and the sodium-coupled and proton coupled systems, which play an important role in the overall process of synaptic transmission.
ScienceBrain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate
470 Citations1969John W. Olney, Lawrence G. Sharpe
With the electron microscope it was observed that dendrites and cell bodies of neurons are the tissue components primarily affected in brain damage induced by monosodium glutamate.
Journal of Biological ChemistryNovel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
469 Citations1987J. Mark Braughler, Jeffery F. Pregenzer +4 more
Two representative compounds from a novel chemical series of potent inhibitors of lipid peroxidation are described and one of the compounds, U74500A, may act as a membrane localized chelator of iron.
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