Opioid receptors in the ventral tegmental area contribute to stress-induced analgesia in the formalin test for tonic pain
Brain ResearchPublished 1 April 1996
Nadège Altier, Jane Stewart
Citations42
SJR quartileQ2
SJR score0.85
SNIP0.72
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TL;DR
It is reported that blockade of opioid receptors by bilateral infusions of naltrexone methylbromide in the ventral tegmental area (VTA) in the midbrain can reduce stress-induced analgesia in this test, indicating that endogeneous opioids act in the VTA to mediate stress-related pain in tonic pain.
Abstract
Exposure to stress can induce analgesia in the formalin test for tonic pain. Here, we report that blockade of opioid receptors by bilateral infusions of naltrexone methylbromide (NMB) (0.1 microgram/0.5 microliter/side) in the ventral tegmental area (VTA) in the midbrain can reduce stress-induced analgesia in this test. These findings indicate that endogeneous opioids act in the VTA to mediate stress-induced analgesia in tonic pain.
Keywords
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