login

Histone Methylation

CellPublished 1 June 2002Open access
Andrew J. Bannister, Robert Schneider, Tony Kouzarides
Citations525
SJR quartileQ1
SJR score22.61
SNIP7.62
View PDF

TL;DR

The methyl group of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci and can be removed by an active process necessary for regulated gene expression.

Abstract

Methylation of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?

Keywords

Biochemistry, Genetics and Molecular Biology