Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails
Genes & DevelopmentPublished 15 September 2001Open access
Yi Zhang, Danny Reinberg
Citations1,504
SJR quartileQ1
SJR score4.00
SNIP1.43
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TL;DR
This work aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the “building blocks” of EMT and its role in cancer progression.
Abstract
Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599-7295, USA; Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Keywords
Biochemistry, Genetics and Molecular Biology
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The Journal of Cell BiologyNOP3 is an essential yeast protein which is required for pre-rRNA processing.
111 Citations1992I. Russell, David Tollervey
A fifth member of this family of nucleolar proteins, NOP3, is cloned and sequenced and shown to be essential for cell viability, and Northern analysis and pulse-chase labeling indicate that pre-rRNA processing is inhibited at the late steps.
PubMedCloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.
101 Citations2001Hideaki Mabuchi, Hidenori FUJII +7 more
The functional domains present within C LLD7 and CLLD8 suggest that the proteins may be involved in critical cellular processes such as cell cycle and transcriptional control and could therefore be directly or indirectly involved in leukemogenesis.
Journal of Biological ChemistryAnalysis of the Yeast Arginine Methyltransferase Hmt1p/Rmt1p and Its in Vivo Function
95 Citations2000Anne McBride, Valerie H. Weiss +3 more
It is demonstrated that the catalytically active form of Hmt1p is required for its activity in vivo, and new aspects of HMT1 are defined and the importance of itsActivity in vivo is revealed.
Current BiologyStochastic WNT signaling between nonequivalent cells regulates adhesion but not fate in the two-cell leech embryo
85 Citations2001Françoise Z. Huang, Alexandra E. Bely +1 more
The findings show that the stochastic phase of HRO-WNT-A signaling in the two-cell stage of Helobdella is negatively regulated by cell-cell contact and that this early signaling affects cell adhesion without affecting cell fate.
Molecular and Cellular BiologyFunctional Interaction between the Coactivator <i>Drosophila</i> CREB-Binding Protein and ASH1, a Member of the Trithorax Group of Chromatin Modifiers
75 Citations2000Frédéric Bantignies, Richard H. Goodman +1 more
The results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dC BP might be involved in the regulation of higher-order chromatin structure.
Biochemical JournalThe G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats
75 Citations1993Caroline M. Milner, R. Duncan Campbell
The class III region of the human major histocompatibility complex spans approx.
BiochemistryRelationship between Methylation and Acetylation of Arginine-Rich Histones in Cycling and Arrested HeLa Cells
70 Citations1995Anthony T. Annunziato, Michelle B. Eason +1 more
It is found that the methylation of H3 is much more targeted to rapidly acetylated chromatin than is the methylations of H4, which largely involves the unacetylated subtype even in the presence of butyrate.
Proceedings of the National Academy of SciencesNegative regulation of mitosis in fission yeast by the Shk1interacting protein Skb1 and its human homolog, Skb1Hs
68 Citations1998Mary Gilbreth, Peirong Yang +5 more
The results indicate that Skb1 negatively regulates mitosis by a mechanism that is independent of the Cdc2-activating phosphatase Cdc25 but that is at least partially dependent on Shk1 and the CDC2 inhibitory kinase Wee1, and provide evidence of a previously undescribed role for PAK-related protein kinases as mitotic inhibitors.
Genes & DevelopmentProteolytic removal of core histone amino termini and dephosphorylation of histone H1 correlate with the formation of condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development.
65 Citations1991Ren-Yong Lin, Richard G. Cook +1 more
The results strongly suggest that the developmentally regulated proteolysis of core histones and dephosphorylation of histone H1 participate in a novel pathway leading to the formation of highly condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development.
Biochemical and Biophysical Research CommunicationsHsl7p, the Yeast Homologue of Human JBP1, Is a Protein Methyltransferase
58 Citations2000Jin‐Hyung Lee, Jeffry R. Cook +4 more
The yeast protein Hsl7p is a sequence and functional homologue of JBP1, a newly characterized protein methyltransferase, and these data provide evidence for an intricate link between protein methylation and macroscopic changes in yeast morphology.
Archives of Biochemistry and BiophysicsMethylation of lysine residues of histone fractions in synchronized mommalian cells
56 Citations1971G.R. Shepherd, J.M. Hardin +1 more
Evidence is presented to demonstrate differential methylation of histone fractions and to substantiate differential temporal coupling of themethylation of specific hist one fractions with histone and DNA biosynthesis.
Journal of Cell ScienceThe regulation of euchromatin and heterochromatin by histones in yeast
55 Citations1995Michael Grunstein, Andreas Hecht +6 more
Both euchromatin and heterochromatin contain nucleosomal particles, however histones have been shown to regulate genes in these regions in quite different ways, and the mechanisms by which such regulation occurs are the topic of this paper.
Cytogenetic and Genome ResearchAssignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids
53 Citations1999Peter J. Harte, Wei Wu +2 more
A human gene encoding an unusual bifurcated SET domain protein containing a large “insertion” between the most highly conserved parts of the SET domain is identified.
Plant Molecular BiologyCloning and developmental expression of pea ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit N-methyltransferase
53 Citations1995Robert R. Klein, Robert L. Houtz
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