Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia
Cochrane Database of Systematic ReviewsPublished 4 September 2014
Helle Krogh Johansen, Peter C Gøtzsche
Citations74
SJR quartileQ1
SJR score1.62
SNIP2.04
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TL;DR
It is not clear whether there are any advantages of lipid-based formulations if conventional amphotericin B is administered under optimal circumstances, and their high cost prohibits routine use in most settings.
Abstract
It is not clear whether there are any advantages of lipid-based formulations if conventional amphotericin B is administered under optimal circumstances, and their high cost prohibits routine use in most settings. There is a need for large trials comparing lipid-based formulations of amphotericin B with conventional amphotericin B given in the same dose, with routine premedication for prevention of infusion-related toxicity, and with supplementation with fluid, potassium, and magnesium for prevention of nephrotoxicity.
Keywords
Medicine
The Journal of Infectious DiseasesInfectious Diseases Society of America
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