Endothelial function is impaired in fit young adults of low birth weight
Cardiovascular ResearchPublished 1 December 1998
Jonathan Goodfellow
Citations173
SJR quartileQ1
SJR score3.95
SNIP2.66
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The findings suggest that endothelial dysfunction is a consequence of foetal malnutrition, consistent with contributing to the clinical features of the 'Small Baby Syndrome' in later adult life.
Abstract
The findings suggest that endothelial dysfunction is a consequence of foetal malnutrition, consistent with contributing to the clinical features of the 'Small Baby Syndrome' in later adult life.
Keywords
MedicineNursing
DiabetesRole of Insulin Resistance in Human Disease
12,152 Citations1988Gerald M. Reaven
The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.
NatureThe pathogenesis of atherosclerosis: a perspective for the 1990s
10,638 Citations1993Russell Ross
The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
The LancetNon-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
4,733 Citations1992David S. Celermajer, Keld E. Sørensen +6 more
Endothelial dysfunction is present in children and adults with risk factors for atherosclerosis, such as smoking and hypercholesterolaemia, before anatomical evidence of plaque formation in the arteries studied, suggesting this may be an important early event in atherogenesis.
BMJFetal origins of coronary heart disease
3,540 Citations1995D.J.P. Barker
The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease.
DiabetologiaType 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
3,279 Citations1992C. N. Hales, David J.P. Barker
It is proposed that one of the major long-term consequences of inadequate early nutrition is impaired development of the endocrine pancreas and a greatly increased susceptibility to the development of Type 2 diabetes.
The LancetINFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
2,871 Citations1986David J.P. Barker
Although the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas.
New England Journal of MedicineHyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease
1,700 Citations1996Jean‐Pierre Després, Benoı̂t Lamarche +5 more
High fasting insulin concentrations appear to be an independent predictor of ischemic heart disease in men after adjustment for other risk factors.
CirculationNitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo
1,619 Citations1995Robinson Joannidès, Walter E. Haefeli +5 more
No, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries, and this response can be used as a test for the L-arginine/NO pathway in clinical studies.
Journal of Clinical InvestigationHyperinsulinemia. A link between hypertension obesity and glucose intolerance.
1,484 Citations1985Michaela Modan, Hillel Halkin +6 more
It is concluded that insulin resistance and/or hyperinsulinemia are present in the majority of hypertensives, constitute a common pathophysiologic feature of obesity, glucose intolerance, and hypertension, possibly explaining their ubiquitous association, and may be linked to the increased peripheral vascular resistance of hypertension, which is putatively related to elevated intracellular sodium concentration.
New England Journal of MedicineHypertension and Associated Metabolic Abnormalities — The Role of Insulin Resistance and the Sympathoadrenal System
1,446 Citations1996Gerald M. Reaven, Hans Lithell +1 more
It is hypothesized that the metabolic abnormalities linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts influence on blood pressure and complications in many patients.
Journal of Clinical InvestigationInsulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
1,217 Citations1994Helmut O. Steinberg, Ginger Brechtel +3 more
Insulin vasodilation of skeletal muscle vasculature most likely occurs via increasing EDNO synthesis/release, and insulin appears to be a novel modulator of the EDNO system.
Journal of Clinical InvestigationSkeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.
783 Citations1987Stephen Lillioja, Andrew A. Young +8 more
The data suggest that diffusion distance from capillary to muscle cells or some associated biochemical change, and fiber type, could play a role in determining in vivo insulin action and may provide at least a partial explanation for the insulin resistance associated with obesity.
DiabetologiaThinness at birth and insulin resistance in adult life
708 Citations1994David I. W. Phillips, David J.P. Barker +3 more
It is concluded that insulin resistance is associated with impaired development in fetal life and men and women who were thin at birth, as measured by a low ponderal index, were more insulin resistant.
Annals of Internal MedicineEstrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women
703 Citations1994Eric H. Lieberman, Marie D. Gerhard +6 more
It is hypothesized that long-term estrogen administration would improve vasomotor function in postmenopausal women and was conducted in a double-blind, randomized, crossover, placebo-controlled trial.
Clinical ScienceIncreased Systolic Blood Pressure in Adult Rats Induced by Fetal Exposure to Maternal Low Protein Diets
686 Citations1994Simon C. Langley‐Evans, Alan A. Jackson
Pregnant rats demonstrated a graded response to the diets, with those fed 9 and 6% protein tending to consume less energy and gain less weight than 18% protein fed controls, and an inverse relationship between maternal protein intake and the systolic blood pressure of the offspring was observed.
Biology of the NeonateEffect of a Low Protein Diet during Pregnancy on the Fetal Rat Endocrine Pancreas
651 Citations2009Anne Snoeck, Claude Remacle +2 more
Two different morphometric analyses showed that in the LP neonate B-cell proliferation and islet size were reduced in the head of the pancreas and in the pancreatic tail, these parameters were also decreased but to a lesser extend.
CirculationPhysical Training Improves Endothelial Function in Patients With Chronic Heart Failure
626 Citations1996Burkhard Hornig, V. Maier +1 more
Results indicate that physical training restores FDD in patients with chronic heart failure, possibly by enhanced endothelial release of nitric oxide.
Diabetesβ-cells in type II diabetes mellitus
585 Citations1991Daniel Porte
Type II diabetes is reviewed as a heterogenous disorder in which islet dysfunction plays a critical role and is suggested that pro-IAPP and proinsulin processing and mature peptide secretion normally occur together and that abnormal processing, secondary to or in conjunction with defects in hormone secretion, lead to progressive accumulation of intracellular IAPP and IAPP, which in cats, monkeys, and humans form intrACEllular fibrils and amyloid deposits.
CirculationModulation of Endothelium-Dependent Flow-Mediated Dilatation of the Brachial Artery by Sex and Menstrual Cycle
569 Citations1995Masayoshi Hashimoto, Masahiro Akishita +8 more
Investigation of the effects of sex and menstrual cycle on endothelium-dependent flow-mediated vasodilatation found that the endogenous estradiol may be involved in this menstrual cycle-related vasodilation.
New England Journal of MedicineEvidence of Impaired Endothelium-Dependent Coronary Vasodilatation in Patients with Angina Pectoris and Normal Coronary Angiograms
564 Citations1993Kensuke Egashira, T Inou +4 more
It is suggested that endothelium-dependent dilatation of the resistance coronary arteries is defective in patients with anginal chest pain and normal coronary arteries, which may contribute to the altered regulation of myocardial perfusion in these patients.
Ultrasound in Medicine & BiologyAssessment of the distensibility of superficial arteries
477 Citations1990A.P.G. Hoeks, Peter J. Brands +2 more
It can be concluded that a RF-signal memory in combination with a PC provides a useful tool to extract detailed diameter waveforms from theRF-signals obtained.
DiabetesImpaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM
457 Citations1992Markku Laakso, Steven V. Edelman +2 more
DiabetesIslet Function in Offspring of Mothers on Low-Protein Diet During Gestation
447 Citations1991S. Dahri, Anne Snoeck +3 more
This study demonstrated an impairment of insulin secretion of these fetal islets when stimulated in vitro with amino acids such as arginine and leucine, and stressed the impact of a balanced diet with qualitative and quantitative amino acid composition for the fetal endocrine pancreas to develop normally, without lasting functional and structural consequences in adulthood.
Diabetic MedicineFetal Growth and Glucose and Insulin Metabolism in Four‐year‐old Indian Children
380 Citations1995Chittaranjan S. Yajnik, Caroline Fall +7 more
The findings suggest that Indian children with reduced intra‐uterine growth have reduced glucose homeostasis after a glucose challenge, consistent with the hypothesis that Type 2 diabetes mellitus in India may be programmed in fetal life.
HypertensionSkeletal muscle blood flow. A possible link between insulin resistance and blood pressure.
370 Citations1993A. D. Baron, G Brechtel-Hook +2 more
Testing the hypothesis that reduced skeletal muscle blood flow in response to insulin may at least partially account for the wide range of insulin sensitivity observed in normotensive subjects found it to be inversely proportional to the height of the baseline mean arterial pressure.
FEBS LettersUp‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells
346 Citations1995Keiichi Hishikawa, Toshio Nakaki +4 more
The results provide evidence that human endothelial NO synthase can be regulated by estrogens, and clarified that increased NO production by 17β‐estradiol treatment was accompanied by increased No synthase protein.
NatureEDRF coordinates the behaviour of vascular resistance vessels
318 Citations1987Tudor M. Griffith, D. H. Edwards +3 more
It is demonstrated that EDRF can coordinate the aggregate hydrodynamic properties of an intact network and maintains a fourth-power relationship between diameter and flow so that the pressure gradient in each vessel asymptotically approaches a constant value at high flow rates.
CirculationDefective <scp>l</scp> -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients
309 Citations1996Stefano Taddei, Agostino Virdis +4 more
Offspring of essential hypertensive patients are characterized by a reduced response to acetylcholine linked to a defect in the nitric oxide pathway, suggesting that an impairment in nitricoxide production precedes the onset of essential hypertension.
CirculationFlow-Mediated Dilation in 9- to 11-Year-Old Children
304 Citations1997C. P. M. Leeson, Peter H. Whincup +5 more
Low birth weight is associated with impaired endothelial function in childhood, a key early event in atherogenesis, and growth in utero may be associated with long-term changes in vascular function that are manifest by the first decade of life and that may influence the long- term risk of cardiovascular disease.
CirculationEndothelial Control of Arterial Distensibility Is Impaired in Chronic Heart Failure
279 Citations1995M W Ramsey, Jonathan Goodfellow +4 more
It is indicated that conduit artery distensibility is increased by acetylcholine and increased blood flow in healthy subjects but not in CHF patients, whereas the effects of adenosine and GTN on Distensibility are preserved in ChF patients.
DiabetologiaThe relationships of concentrations of insulin, intact proinsulin and 32?33 split proinsulin with cardiovascular risk factors in Type 2 (non-insulin-dependent) diabetic subjects
199 Citations1990Dinesh Nagi, T J Hendra +7 more
High concentrations of insulin-like molecules are associated with changes in recognised cardiovascular risk factor in patients with Type 2 (non-insulin-dependent) diabetes mellitus.
American Journal of Physiology-Endocrinology and MetabolismAltered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams
191 Citations1996Susan E. Ozanne, George Davey Smith +2 more
The anomalous response to insulin indicates changes in its metabolic signaling, but normal insulin binding suggests that this alteration is a postreceptor event.
HeartSt Cyres lecture. Endothelium in control.
163 Citations1991A.H. Henderson
The greatest growth area in cardiovascular science over recent years must surely be in the role of endothelium, and just one-namely the production of EEDRF is considered, a powerful vasodilator substance released from the endothelia of all blood vessels of all species studied.
Clinical ChemistryEnzyme immunoassay for factor VIII-related antigen.
161 Citations1982Jan Čejka
The simplicity and specificity of the ELISA technique should make it a useful alternative to the more difficult and time-consuming Laurell method.
PubMedThe role of insulin in prenatal growth.
159 Citations1989Abigail L. Fowden
Mise en evidence de la preponderance de l'insuline dans le developpement et la croissance normale du foetus humain, dans the regulation de la composition corporelle, de the croissance du squelette et des tissus foetaux.
American Journal of Physiology-Gastrointestinal and Liver PhysiologyProgramming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet
152 Citations1997Mina Desai, Christopher D. Byrne +4 more
The effect of programming metabolism extends not only to protein biochemistry but possibly also to the regulation of gene expression in offspring of dams fed either a 20% protein or an isocaloric 8% protein diet during pregnancy and lactation.
DiabetologiaFetal growth and insulin secretion in adult life
125 Citations1994David I. W. Phillips, S. Hirst +3 more
The results argue against a major role for defective insulin secretion as a cause of glucose intolerance in adults who were growth retarded in pre-natal life.
The LancetHyperinsulinaemia and microvascular angina ("syndrome X")
121 Citations1991Christopher J. Jones, S.J. Hutchison +3 more
A role for increased concentrations of insulin in coronary microvascular dysfunction is suggested in patients with angina attributed to microVascular coronary dysfunction and healthy subjects matched for age, sex, and body mass.
Life SciencesSex differences in concentrations of exhaled nitric oxide and plasma nitrate
113 Citations1996Bernd Jilma, Johannes Kästner +6 more
Sex differences in NO-generation are studied by measuring single breath NO-exhalation and plasma levels of nitrate (NO3), the stable endmetabolite of NO, by measuring male and female volunteers at weekly intervals.
BMJRelation between birth weight at term and systolic blood pressure in adolescence
98 Citations1994J Matthes, PS Lewis +2 more
Systolic blood pressure in adolescents of low birth weight is not significantly different from that of adolescents of normal birth weights, as measured by random zero sphygmomanometry.
The LancetInsulin resistance in microvascular angina (syndrome X)
96 Citations1993Hans Erik Bøtker, J. P. Bagger +5 more
It was found that microvascular angina was associated with substantial insulin resistance, and whether this relation is causal or coincidental is as yet unsettled.
CirculationChronic Inhibition of Endothelium-Derived Nitric Oxide Synthesis Causes Coronary Microvascular Structural Changes and Hyperreactivity to Serotonin in Pigs
89 Citations1995Akira Itô, Kensuke Egashira +8 more
It is indicated that chronic administration of L-NAME caused coronary microvascular structural changes and hyperreactivity to serotonin in pigs in vivo, suggesting an important role of defective NO synthesis in coronary microVascular disorders.
American Journal of HypertensionSustained Hypertension in the Rat Induced by Chronic Blockade of Nitric Oxide Production
87 Citations1992Robert A. Johnson, Ronald K. Freeman
The results from this simple experimental model suggest that chronic blockade of nitric oxide synthesis results in sustained arterial hypertension that is not enhanced by sodium loading.
Developments in cardiovascular medicineSkeletal muscle blood flow
67 Citations1993Thierry H. LeJemtel, Stuart D. Katz
Clinical ChemistryStandardization (External and Internal) of HPLC Assay for Plasma Homocysteine
55 Citations1997Khim Kuo, Rachel Still +2 more
This method has been modified by adding cysteamine hydrochloride as an internal standard to the plasma or homocysteine calibrator to compensate for variations in thiol derivatization and sample injection procedures.
UCL Discovery (University College London)Normal ranges for brachial artery flow-mediated dilatation: A non-invasive ultrasound test of arterial endothelial function
38 Citations1996Adams, J. Robinson +3 more
It is demonstrated that flow-mediated dilatation of the human brachial artery occurs in subjects without vascular risk factors and is inversely related to vessel size.
DiabetologiaSuboptimal protein nutrition in early life later influences insulin action in pregnant rats
37 Citations1996M J Holness, M C Sugden
It is demonstrated that growth retardation evoked by suboptimal protein nutrition during early life leads to decreased basal glucose turnover and glucose utilization by a range of maternal tissues and the fetus during a subsequent pregnancy.
The LancetNon-invasive detection of endothelial dysfunction
37 Citations1996Mark Ramsey, Jonathan Goodfellow +3 more
Journal of HypertensionEpidemiology of hypertension and insulin resistance syndrome
36 Citations1997Steven M. Haffner
It is possible that the relation between insulin, blood pressure and atherosclerosis may be weaker in blacks, however, antihypertensive agents that worsen insulin resistance may further increase the risk of NIDDM already present in subjects with hypertension.
Diabetic MedicineNutrition in Pregnancy and the Concentrations of Proinsulin, 32-33 Split Proinsulin, Insulin, and C-peptide in Cord Plasma
30 Citations1996Keith M. Godfrey, Siân Robinson +4 more
MetabolismInsulin sensitivity in familial hypercholesterolemia
28 Citations1993Alfredo Quiñones Galvan, D Santoro +6 more
The ability of exogenous hyperinsulinemia to stimulate carbohydrate oxidation and energy expenditure and suppress lipid oxidation and plasma FFA and potassium levels was equivalent in FHC and control subjects.
International Journal of CardiologyEndothelial dysfunction: a reversible clinical measure of atherogenic susceptibility and cardiovascular inefficiency
23 Citations1997A.H. Henderson
The serendipitous discovery of this endoinfluence of endothelium to its immediately subjacent thelium-derived relaxant factor (EDRF) was vascular smooth muscle and the story, yet to be fully told, well exemplifies the fascinating unpredictability of research and the vistas it can unexpectedly open up.
Current Opinion in LipidologyThe role of the endothelium in atherogenesis
17 Citations1993Paul E. DiCorleto, Abigail A. Soyombo
The Journal of Clinical Endocrinology & MetabolismHyperinsulinemia in patients with hypercholesterolemia.
17 Citations1992Giuseppe Paolisso, Eleuterio Ferrannini +3 more
Patients with type IIa familial combined hyperlipoproteinemia hypercholesterolemia was associated with hyperinsulinemia even when controlling for other confounders (age, gender, body mass, glucose tolerance, and blood pressure).
Diabetes Research and Clinical PracticeCardiovascular Syndromes X, endothelial dysfunction and insulin resistance
16 Citations1996Jonathan Goodfellow, David R. Owens +1 more
Cardiac Syndrome X (microvascular angina) and the more recently described metabolic SyndromeX (an epidemiological association between insulin resistance and atheroma, dyslipidaemia, and hypertension) may have more in common than the chance of their common sobriquet.