Recombinant Leptin for Weight Loss in Obese and Lean Adults
JAMAPublished 27 October 1999
Steven B. Heymsfield, Andrew S. Greenberg, Ken Fujioka, Russell M. Dixon, Robert F. Kushner, Thomas E. Hunt
Citations1,422
SJR quartileQ1
SJR score5.35
SNIP10.71
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TL;DR
Administration of exogenous leptin appears to induce weight loss in some obese subjects with elevated endogenous serum leptin concentrations and a dose-response relationship with weight and fat loss was observed with subcutaneous recombinant leptin injections in both lean and obese subjects.
Abstract
A dose-response relationship with weight and fat loss was observed with subcutaneous recombinant leptin injections in both lean and obese subjects. Based on this study, administration of exogenous leptin appears to induce weight loss in some obese subjects with elevated endogenous serum leptin concentrations. Additional research into the potential role for leptin and related hormones in the treatment of human obesity is warranted.
Keywords
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